八珍汤加减联合穴位艾灸对放化疗子宫颈癌患者免疫水平及生存质量的影响研究

Effect of Modified Bazhen Decoction Combined with Acupoint Moxibustion on Immune Level and Quality of Life of Patients with Cervical Cancer Undergoing Radiotherapy and Chemotherapy

目的:探讨八珍汤加减联合穴位艾灸对放化疗子宫颈癌患者细胞免疫、红细胞免疫以及生存质量的影响。方法:以北大荒集团总医院2019年5月-2020年12月收治的156例子宫颈癌患者为研究对象,根据随机数字表法将其分为对照组和研究组,各78例。对照组采取放化疗结合的方式治疗,研究组在对照组治疗基础上联用八珍汤加减和穴位艾灸。疗程结束后比较两组患者临床疗效;比较两组患者治疗前、治疗后10 d细胞免疫指标(CD3^(+)、CD4^(+)和CD4^(+)/CD8^(+))、红细胞花环率(ATER)、直向肿瘤红细胞花环率(DTER)、免疫黏附促进因子(FEER)、免疫黏附抑制因子(FEIR)以及生存质量;比较两组患者用药期间不良反应发生情况。结果:对照组临床总有效率为80.77%,低于研究组的92.31%(P<0.05)。两组治疗前CD3^(+)、CD4^(+)和CD4^(+)/CD8^(+)比较,差异均无统计学意义(P>0.05),治疗后10 d两组的CD3^(+)、CD4^(+)和CD4^(+)/CD8^(+)均升高,研究组均显著高于对照组(P<0.05)。两组治疗前ATER、DTER、FEER和FEIR比较,差异均无统计学意义(P>0.05),治疗后10 d两组ATER、DTER、FEER均有所升高,研究组均显著高于对照组(P<0.05);两组治疗后10 d FEIR均低于治疗前,研究组显著低于对照组(P<0.05)。两组治疗前QOL和KPS评分比较,差异均无统计学意义(P>0.05),治疗后10 d两组QOL和KPS评分均有所升高,研究组升高更为显著(P<0.05)。两组患者用药期间各项不良反应发生率比较,差异均无统计学意义(P>0.05)。结论:八珍汤加减联合穴位艾灸能有效提升放化疗子宫颈癌患者临床效果,改善患者细胞免疫和红细胞免疫指标,提升生存质量。

Objective:To investigate the effects of modified Bazhen Decoction combined with acupoint moxibustion on cellular immunity,erythrocyte immunity and quality of life in patients with cervical cancer undergoing radiotherapy and chemotherapy.Method:A total of 156 patients with cervical cancer admitted to Beidahuang Group General Hospital from May 2019 to December 2020 were selected as the research subjects,and they were divided into control group and research group according to the random number,with 78 cases in each group.The control group was treated with radiotherapy and chemotherapy,and the research group was treated with modified Bazhen Decoction and acupoint moxibustion.The clinical efficacy of the two groups was compared after the treatment course.Cellular immune indexes(CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)),ATER,DTER,FEER,FEIR and the quality of life before and 10 d after treatment were compared between the two groups.The incidence of adverse reactions was compared between the two groups.Result:The total clinical effective rate in the control group was 80.77%,which was lower than 92.31%in the research group(P<0.05).There were no significant differences in CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)between the two groups before treatment(P>0.05).10 d after treatment,CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the two groups increased,and those of the research group were significantly higher than those of the control group(P<0.05).There were no significant differences between the two groups in ATER,DTER,FEER and FEIR before treatment(P>0.05).10 days after treatment,ATER,DTER and FEER in the two groups were increased,and those of the research group were significantly higher than those of the control group(P<0.05);after 10 days of treatment,FEIR in both groups were lower than those before treatment,and that in the research group was significantly lower than that in the control group(P<0.05).There were no significant differences in QOL and KPS scores between the two groups before treatment(P>0.05).QOL and KPS scores increased in both groups 10 d after treatment,and the increase was more significant in the research group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Modified Bazhen Decoction combined with acupoint moxibustion can effectively improve the clinical effect of radiotherapy and chemotherapy in patients with cervical cancer,improve the indicators of cellular immunity and erythrocyte immunity,and improve the quality of life.