甘精胰岛素联合门冬胰岛素对新诊断2型糖尿病患者生化指标的影响

Effect of Insulin Glargine Combined with Insulin Aspartic on Biochemical Index in Newly Diagnosed Type 2 Diabetes

目的:探讨甘精胰岛素联合门冬胰岛素对新诊断2型糖尿病患者生化指标的影响。方法:选取2019年1月-2021年1月在佳木斯市中医医院接受治疗的100例新诊断2型糖尿病患者,按照随机数字表法将其分为对照组与研究组,每组50例。对照组采用门冬胰岛素治疗,研究组在对照组基础上加用甘精胰岛素治疗。比较两组不良反应发生情况、血糖水平[餐后2 h血糖(2 h PG)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)]、生化指标。结果:研究组不良反应发生率为6.0%,低于对照组的28.0%,差异有统计学意义(P<0.05)。治疗前,两组HbA1c、FPG、2 h PG水平比较,差异均无统计学意义(P>0.05);治疗后,两组HbA1c、FPG、2 h PG水平均低于治疗前,且研究组均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组血肌酐、尿微量白蛋白、24 h尿蛋白定量、总胆固醇、甘油三酯、尿素氮水平比较,差异均无统计学意义(P>0.05);治疗后,研究组血肌酐、尿微量白蛋白、24 h尿蛋白定量、总胆固醇、甘油三酯、尿素氮水平均低于对照组,差异均有统计学意义(P<0.05)。结论:对2型糖尿病患者进行甘精胰岛素联合门冬胰岛素治疗,效果理想,可改善患者生化指标及血糖水平,且不良反应发生率较低。因此,甘精胰岛素、门冬胰岛素治疗值得广泛应用。

Objective:To investigate the effect of Insulin Glargine combined with Insulin Aspartic on biochemical index in newly diagnosed type 2 diabetes.Method:A total of 100 patients with newly diagnosed type 2 diabetes treated in Jiamusi Hospital of Traditional Chinese Medicine from January 2019 to January 2021 were selected,they were divided into control group and study group according to random number table method,with 50 cases in each group.The control group was treated with Insulin Aspartic,and the study group was treated with Insulin Glargine on the basis of the control group.The incidence of adverse reactions,blood glucose levels[2 h postprandial blood glucose(2 h PG),fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c)],biochemical indexes were compared between two groups.Result:The incidence of adverse reactions in the study group was 6.0%,which was lower than 28.0%in the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in HbA1c,FPG and 2 h PG levels between two groups(P>0.05);after treatment,the levels of HbA1c,FPG and 2 h PG in both groups were lower than those before treatment,and the those in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in serum creatinine,urine microalbumin,24 h urinary protein,total cholesterol,triglyceride and urea nitrogen levels between two groups(P>0.05);after treatment,serum creatinine,urine microalbumin,24 h urinary protein,total cholesterol,triglyceride and urea nitrogen levels in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Treatment of Insulin Glargine and Insulin Aspartic in type 2 diabetes patients is ideal,which can improve biochemical indicators and blood glucose level,with low incidence of adverse reactions.Therefore,Insulin Glargine and Insulin Aspartic deserve wide application.