葛根芩连汤治疗肠道疾病的研究进展

Progress in treatment of intestinal diseases with Gegen Qinlian decoction

葛根芩连汤是中医经典复方,现代研究表明其具有抗氧化、抗炎、增强机体免疫、保护肠黏膜屏障以及调节肠道菌群等多种药理作用.葛根芩连汤用于治疗多种肠道疾病,体现了中医学异病同治的辨治特色,其同治机制可能与其具有调节肠道菌群、抗炎和维护肠道屏障功能有关.本文从感染性腹泻、腹泻型肠易激综合征、溃疡性结肠炎和结直肠癌四种肠道疾病的发病因素、病机以及葛根芩连汤对其疗效机制和临床研究方面出发,探讨葛根芩连汤对于肠道疾病的作用,以冀为葛根芩连汤治疗肠道疾病提供更多理论依据.

Gegen Qinlian decoction is a classical compound prescription of traditional Chinese medicine,and modern research shows that it has many pharmacological effects,such as anti-oxidative,anti-inflammatory,immunity-enhancing,intestinal mucosal barrier-protecting,and intestinal flora-regulating effects.Gegen Qinlian decoction has been used to treat various intestinal diseases,which embodies the dialectical treatment feature of“treating the same disease with different therapies”in traditional Chinese medicine;its mechanism of“treating the same disease”may be related to regulating the intestinal flora,anti-inflammation,regulating immunity,and maintaining intestinal barrier function.This article reviews the pathogenic factors and pathogenesis of infectious diarrhea,irritable bowel syndrome-diarrhea,ulcerative colitis,and colorectal cancer,as well as the therapeutic mechanism and clinical research of Gegen Qinlian decoction in treating these intestinal diseases,and explores the effect of Gegen Qinlian decoction on intestinal diseases,with an aim to provide a theoretical basis for treating intestinal diseases with Gegen Qinlian decoction.