摘要
cGAS-STING信号通路是固有免疫系统的重要组成部分,可以触发以Ⅰ型干扰素(interferon type 1,IFN-1)为代表的一系列炎症因子的表达,其在感染性疾病、自身免疫性疾病及肿瘤等多种疾病中发挥着重要作用.近年来,研究发现cGAS-STING信号通路与肝脏疾病的进展密切相关.本文就cGAS-STING信号通路在慢性乙型肝炎、酒精性肝病、非酒精性脂肪性肝病、肝癌等常见肝脏疾病中的作用及其在肝脏疾病治疗中的应用现状作一综述.
The cGAS-STING signaling pathway is an important part of the innate immune system,which could trigger the expression of a series of inflammatory factors represented by interferon type 1(IFN-1).This pathway plays an important role in many diseases such as infectious diseases,autoimmune diseases,and tumors.In recent years,it has been found that the cGAS-STING signaling pathway is important in the physiological and pathological processes of the liver,and is closely related to the progression of liver diseases.This paper reviews the role of the cGAS-STING signaling pathway in common liver diseases such as chronic hepatitis B,alcoholic liver disease,nonalcoholic fatty liver disease,and liver cancer,as well as its application in the treatment of liver diseases.
作者
魏霞
张定棋
张霖璋
刘伟
刘平
徐莹
Xia Wei;Ding-Qi Zhang;Lin-Zhang Zhang;Wei Liu;Ping Liu;Ying Xu(Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Key Laboratory of Liver and Kidney Diseases(Ministry of Education)&Shanghai Key Laboratory of Traditional Chinese Clinical Medicine,Institute of Liver Diseases,Shuguang Hospital,Shanghai 201203,China;Shanghai University of Traditional Chinese Medicine,Key Laboratory of Liver and Kidney Diseases(Ministry of Education)&Shanghai Key Laboratory of Traditional Chinese Clinical Medicine,Institute of Liver Diseases,Shuguang Hospital,Shanghai 201203,China)
出处
《世界华人消化杂志》
CAS
2022年第15期674-679,共6页
World Chinese Journal of Digestology
基金
国家自然基金青年科学基金项目,No.82004162
国家自然科学基金重点项目,No.82130120
上海市青年科技英才扬帆计划,No.20yf1449500
中国博士后基金,No.2020M681367.
