肿瘤相关性低磷性骨软化症的研究进展

Research Progress on Tumor-induced Osteomalacia

肿瘤相关性低磷性骨软化症,又称为瘤源性骨软化症,是由于肿瘤分泌成纤维细胞生长因子-23等调磷因子使肾脏磷丢失增多,导致低磷血症,引起骨基质矿化障碍的获得性代谢性疾病,是一种少见的副瘤综合征。该病发病率低,且临床表现不典型,易漏诊及误诊。该文通过对肿瘤特征、发病机制、临床表现、实验室检查、肿瘤定位、治疗方法以及难治结局的危险因素等方面进行综述,旨在提高临床医生对该病的认识。

Tumor-induced osteomalacia,also known as oncogenic osteomalacia,is an acquired metabolic disease of bone matrix mineralization disorder caused by increased phosphorus loss in the kidney due to autonomous secretion of fibroblast growth factor 23 and other phosphorus-regulating factors by tumors.It is one of the rare paraneoplastic syndromes.The incidence of this disease is low,and the clinical manifestations are untypical,which easily lead to missed diagnosis and misdiagnosis.In this review,the characteristics,pathogenesis,clinical manifestations,laboratory examinations,tumor localization,treatment and risk factors leading to refractory outcomes of the tumor are summarized in order to improve the recognition of the disease among clinical practioners.