中药复方及单体成分调节自噬改善骨关节炎的研究进展

Research Progress on Chinese Medicinal Compound and Monomer Regulating Autophagy in Improving OA

骨关节炎为临床常见的慢性筋骨退行性疾病,也是致残的主要原因之一,由于发病率高且发病机制仍未阐明,如何防治该病成为亟待解决的难题。自噬是细胞维持代谢平衡以及细胞器更新的重要自我平衡机制,随着相关研究的不断深入,发现自噬在骨关节炎的进展过程中有不可忽视的作用。中医学在防治骨关节疾病中有着显著疗效,随着中医药现代化进程的推进,不断涌现的研究证实中药可通过调控细胞自噬水平发挥治疗OA的作用。本文就中药通过调控自噬治疗骨关节炎的相关研究进行综述,以期为后续中药防治骨关节炎的深入研究提供思路。

Osteoarthritis(OA)is a common chronic degenerative disease in clinic,and it is also one of the main causes of disability.Due to the high incidence and unclear pathogenesis,how to prevent and treat the disease has become a difficult problem to be solved.Autophagy is an important homeostasis mechanism for cells to maintain metabolic balance and organelle renewal.With the deepening of related studies,autophagy has been found to play a significant role in the intervention of OA progression.TCM has a significant efficacy in the prevention and treatment of bone and joint diseases.With the modernization of Chinese medicinal,more and more studies have found that Chinese medicinal can play a role in the treatment of OA by regulating the level of autophagy in chondrocytes.This study reviewed the relevant studies on the treatment of OA by regulating autophagy with Chinese medicinal,aiming to provide ideas for the follow-up in-depth researches on the prevention and treatment of OA with Chinese medicinal.