慢性胃炎患者OLGA及OLGIM分期与胃癌的相关性研究

Correlation between OLGA/OLGIM staging and gastric cancer

目的新疆地区慢性胃炎患者OLGA(可操作的与胃癌风险联系的萎缩评估)及OLGIM(可操作的与胃癌风险联系的肠化生评估)分期与胃癌的关系,并进一步探讨OLGA及OLGIM分期与胃癌病变部位的关系。方法回顾性收集2018年1月至2021年4月新疆维吾尔自治区人民医院住院行胃镜并取五块活检的211例胃癌患者的临床及病理资料,通过年龄与性别匹配211例非胃癌对照组。根据OLGA分期和OLGIM分期系统进行分期,通过Logistic回归分析,明确OLGA及OLGIM分期与胃癌的相关性;分析OLGA及OLGIM分期与胃癌病变部位的关系。结果单因素分析中,H.pylori感染,吸烟,饮酒,家族史,OLGA分期、OLGIM分期与胃癌相关(P<0.05);进一步多因素回归分析中,H.pylori感染(OR 0.276,95%CI:0.132-0.575,P=0.001)、吸烟(OR 0.523,95%CI:0.340-0.803,P=0.003)、饮酒(OR 0.412,95%CI:0.266-0.673,P<0.001)、家族史(OR 0.255,95%CI:0.114-0.572,P<0.001)及OLGIM分期Ⅰ期(OR 1.847,95%CI:1.105-3.087,P=0.019)、Ⅱ期(OR 2.004,95%CI:1.087-3.694,P=0.026)、Ⅲ期(OR 7.691,95%CI:2.710-21.828,P<0.001)为胃癌的危险因素。另根据Sperman相关性分析发现OLGA及OLGIM分期与胃癌病变部位无显著相关性(P>0.05)。结论OLGIM分期与胃癌相关,随着OLGIM分期越高,发生胃癌风险增加,而OLGA分期与胃癌无明显相关性。另OLGA及OLGIM分期与胃癌病变部位无显著相关性。

Objective To investigate the relationship between OLGA(Operative Link on Gastritis Assessment)and OLGIM(Operative Link on Gastric Intestinal Metaplasia Assessment)staging and gastric cancer in patients with chronic gastritis in Xinjiang,and to further explore the relationship between OLGA and OLGIM staging and the location of gastric cancer.Methods The clinical and pathological data of 211 patients with gastric cancer who underwent gastroscopy and five piece biopsy in the people's Hospital of Xinjiang Uygur Autonomous Region from January 2018 to April 2021 were collected.Through age and gender matching,211 not gastric cancer control groups were matched by age and gender.They were staged according to OLGA staging and OLGIM staging,Logistic regression analysis was used to clarify the correlation between OLGA and OLGIM staging and gastric cancer.According to Sperman correlation analysis,the relationship between OLGA and OLGIM stages and the lesion location of gastric cancer was clarified.Results Among 211 patients with gastric cancer,there was significant difference in H.pylori infection,smoking,drinking,family history,OLGA stage,OLGIM stage between gastric cancer and non gastric cancer groups(P<0.05);In univariate analysis,H.pylori infection,smoking,alcohol consumption,family history,OLGA stage,OLGIM stage was associated with gastric cancer(P<0.05).In further multivariate regression analysis,H.pylori infection(OR值0.276,95%CI:0.132-0.575,P=0.001),smoking(OR值0.523,95%CI:0.340-0.803,P=0.003),drinking(OR值0.412,95%CI:0.266-0.673,P<0.001);Family history(OR值0.255,95%CI:0.114-0.572,P<0.001),OLGIM stage Ⅰ(OR值1.847,95%CI:1.105-3.087,P=0.019),stage Ⅱ(OR值2.004,95%CI:1.087-3.694,P=0.026),stage Ⅲ(OR值7.691,95%CI:2.710-21.828,P<0.001)were risk factors for gastric cancer.according to Sperman correlation analysis,There was no significant correlation between OLGA and OLGIM stages and the location of gastric cancer(P>0.05).Conclusion OLGIM stage is related to gastric cancer.With the higher OLGIM stage,the risk of gastric cancer increases,while OLGA stage has no significant correlation with gastric cancer.In addition,OLGA and OLGIM stages had no significant correlation with the lesion location of gastric cancer.