三种葡萄醋对高脂饮食大鼠血脂水平的影响

Effects of three kinds of grape vinegar on blood lipid level in rats fed with high-fat diet

以3种葡萄醋为样本,葡萄醋(纯葡萄汁发酵,样品A)、葡萄醋[V(葡萄汁)∶V(药食同源产品)=1∶1发酵,样品B]、市售葡萄醋(样品C),测定其对大鼠血脂水平的影响。将120只KM雄性大鼠随机分为12组,分别灌胃生理盐水、脂肪乳剂和葡萄醋样品,连续灌胃8周后,检测血清、肝脏生化指标及肝脏病理切片,结果表明,与模型组相比,各试验组大鼠体质量均有不同程度的降低,其中A、B样品大鼠在第5周~第7周体质量降低幅度较大;总胆固醇与甘油三酯降低、高密度脂蛋白胆固醇升高、低密度脂蛋白胆固醇降低,其中样品B组与模型组差异较大;各试验组大鼠血清载脂蛋白ApoA1升高、ApoB降低,其中样品B对这2项指标影响最大;大鼠肝脏质量及肝脏系数均有降低,但降低规律并不与样品及剂量高低相关联;与模型组相比,样品B各组及样品A、C高剂量组肝细胞基本恢复正常,其他各组肝细胞均有不同程度的损伤。

In this paper,three kinds of grape vinegars were used as samples,sample A:grape vinegar(pure grape juice fermentation),sample B:grape vinegar(grape juice∶drug food homology material=1∶1 fermentation)and sample C:commercially available grape vinegar.One hundred and twenty KM male rats were randomly divided into 12 groups and gavaged with saline,fat emulsion and grape vinegar,etc.After eight weeks of continuous gavage,serum and liver biochemical indexes and liver pathological sections were examined.Compared with the model group,the body weight of rats in all groups decreased with different degrees,among which the body weight of rats in samples A and B decreased more in the 5^(th) week to the 7^(th) week;TC and TG indexes decreased,HDL-C increased and LDL-C decreased,among which the difference between sample B and the model group was larger;the increase of ApoA1 indexes and the decrease of ApoB indexes,among which the improvement of sample B was the largest for the two indexes;the decrease of liver mass and liver coefficient of rats,but the decrease pattern did not correlate with the sample and the dose;the liver sections showed that compared with the model group,the amount of sample B and the amount of sample A and C high dose groups were basically different.The hepatocytes in the high dose group of sample B and sample A and C were basically restored to normal,while the hepatocytes in other groups were damaged to different degrees.