摘要
阿霉素被广泛用于血液和实体肿瘤的化疗,大大延长了癌症患者的生存期。但与此同时,阿霉素在非癌组织中的蓄积亦可造成“脱靶效应”,即化疗毒副反应,其中以阿霉素心脏毒性最为显著和致命,而目前缺乏阿霉素心脏毒性的有效诊疗手段。近年来,外泌体研究方兴未艾,异质性、稳定性和免疫原性低等优点使其成为众多疾病的良好诊断标志物和治疗载体。本文主要对外泌体中非编码RNA诊治阿霉素心脏毒性的相关研究进行述评。
Doxorubicin(DOX)is widely applied in hematologic and solid tumor chemotherapy,which greatly prolongates the survival time of cancer patients.However,at the same time,the accumulation of DOX in non-cancer tissues also causes“off-target effect”,that is chemotherapy-related toxicity,among which doxorubicin-induced car-diotoxicity(DIC)is the most significant and fatal.However,there is no effective means to diagnose and treat DIC at present.In recent years,studies on exosomes have been in the ascendant.The advantages such as heterogeneity,stability and non-immunogenicity make exosomes ideal diagnostic markers and therapeutic vectors for many diseases.This article mainly aims to review the related studies on the diagnosis and treatment of DIC by non-coding RNA in exosomes.
作者
田超
吴钦超
褚现明
TIAN Chao;WU Qinchao;CHU Xianming(Department of Cardiology,1.the Affiliated Hospital of Qingdao University,Qingdao Shandong 266100;the Affiliated Cardiovascular Hospital of Qingdao University,Qingdao Shandong 266071,China)
出处
《实用心电学杂志》
2022年第4期243-248,共6页
Journal of Practical Electrocardiology
基金
国家自然科学基金资助项目(82172574,81871231)
山东省高等医学教育研究中心科研规划课题项目(YJKT202171)
中华中医药学会课题项目(2021HH-006)
山东省中医药科技项目(2021M164)。