3D打印聚醚醚酮复合材料人工骨的成型参数优化

Optimization of Printing Parameters of 3D Printed Polyetheretherketone Composite Artificial Bone

为了提高3D打印聚醚醚酮(PEEK)人工骨与人骨力学性能匹配度,同时改善PEEK材料生物活性,使用羟基磷灰石(HA)增强生物活性的PEEK丝材,对熔融沉积成型(FDM)PEEK/HA复合材料的成型参数进行了优化。设计了正交试验,对填充方向、打印速度、分层厚度和打印温度等重要因素对试样力学性能的影响规律进行了研究。采用三维全场应变测量分析系统对试样在力学试验中的应变场进行测量,采用微米X射线三维成像系统对试样内部缺陷进行分析,得到了各因素对试样力学性能的影响规律,获得了优化打印参数,并通过细胞黏附与增殖试验验证了PEEK/HA材料的生物相容性。试验结果表明:各因素对拉伸强度的影响程度由大到小依次为打印速度、填充方向、分层厚度、打印温度,最大拉伸强度为69.63 MPa;对弯曲强度的影响程度由大到小依次为填充方向、打印速度、分层厚度、打印温度,最大弯曲强度为99.5 MPa。优化参数打印的PEEK/HA试样的力学性能与人皮质骨相当,且具备了良好的生物活性。

To make the mechanical properties of 3D printed polyetheretherketone(PEEK)artificial bones better match with those of human bones,and to improve the bioactivity of PEEK materials,the parameters for printing PEEK/HA composites through fused deposition molding(FDM)are optimized using PEEK fiber with bioactivity enhanced by hydroxyapatite(HA).Orthogonal experiments are designed to study the effects of important factors such as filling direction,printing speed,layer thickness and printing temperature on the mechanical properties of the specimens.In the mechanical experiment,the strain field of the specimens is measured with the three-dimensional full-field strain measurement and analysis system,and the internal defects of the specimens are analyzed with micron X-ray three-dimensional imaging system to find out the influences of various factors on the mechanical properties of the specimens,so the optimized printing parameters are obtained.The biocompatibility of PEEK/HA material was tested by cell adhesion and proliferation experiment.The experimental results show that the factors rank in this order in terms of their influences on the tensile strength:printing speed,filling direction,delamination thickness,printing temperature,and the maximum tensile strength is 69.63 MPa;and rank in this order in terms of their influences on the bending strength:filling direction,printing speed,delamination thickness,printing temperature,and the maximum bending strength is 99.5 MPa.The PEEK/HA specimens printed with optimized parameters have equivalent mechanical properties of human cortical bone,and have good bioactivity.