p53基因密码子72多态性与口腔癌易感性的荟萃分析

Relationship between p53 codon 72 polymorphism and oral cancer susceptibility:A Meta-analysis

目的:运用荟萃分析方法研究肿瘤抑制因子p53基因密码子72位点多态性与口腔癌易感性的发生风险。方法:检索维普(VIP)、中国知网(CNKI)、万方、中国生物医学文献数据库(CBM)、PubMed、Embase、WebofScience中有关p53基因密码子72位点多态性与口腔癌易感性关联研究的文献,以比值比(odds ratio,OR)和95%CI为效应指标,应用STATA 14软件和RevMan5进行荟萃分析,并对发表偏倚及敏感性分析进行检验。结果:纳入16个病例对照研究,口腔癌病例组共计2317例,正常对照组共计2933例。荟萃分析结果显示:在总人群中,p53基因密码子72位点基因多态性与口腔癌风险之间没有显著关联(Pro vs Arg OR=1.03,95%CI:0.887~1.195;Arg Pro+ProPro vs ArgArg OR=0.957,95%CI:0.847~1.081;ProPro vs ArgArg+ArgPro OR=1.082,95%CI:0.835~1.401;ProProvsArg ArgOR=1.059,95%CI:0.783~1.433;ArgProvsArg ArgOR=0.946,95%CI:0.831~1.076;ArgArg+ProProvsArgProOR=0.943,95%CI:0.842~1.055)。针对种族和对照人群来源设计的亚组分析结果也显示p53基因密码子72多态性与口腔癌风险之间没有显著相关性。结论:p53基因密码子72位点多态性与口腔癌的易感性没有直接关联,p53基因多态性可能不是口腔癌易感性的独立影响因素。

Objective:To study the association between tumor suppressor p53 codon 72 polymorphism and the susceptibility of oral cancer by Meta-analysis.Methods:We conducted a systematic electronic search of the literatures about p53 codon 72 polymorphism and the susceptibility of oral cancer on VIP,CNKI,Wanfang,CBM,PubMed,Embase and Web of Science.Odds ratios(OR)with 95%confidence interval(95%CI)acted as the effect index to estimated Meta-analysis which performed by STATA14 and RevMan5 software,as well as the publication bias and sensitivity analysis were identified.Results:A total of 16 case-control studies with 2317 oral cancer patients and 2933 normal controls were included in the current Meta-analysis.The results demonstrated that the association between p53 codon 72 polymorphism and oral cancer risk were not statistically significant(Pro vs Arg OR=1.03,95%CI:0.887-1.195;ArgPro+ProPro vs ArgArg OR=0.957,95%CI:0.847-1.081;ProPro vs ArgArg+ArgPro OR=1.082,95%CI:0.835-1.401;ProPro vs ArgArg OR=1.059,95%CI:0.783-1.433;ArgPro vs ArgArg OR=0.946,95%CI:0.831-1.076;ArgArg+ProPro vs ArgPro OR=0.943,95%CI:0.842-1.055).Subgroup analysis based on ethnicity and source of normal control population further identified the p53 codon 72 polymorphism was not linked to oral cancer risk.Conclusion:The polymorphism of p53 codon 72 polymorphism is not directly associated with the susceptibility of oral cancer,which maybe not an independent factor of the susceptibility of oral cancer.