摘要
Emerging evidence that Enterovirus A 71(EV-A71)infection closely related to apoptosis.The ZVAD is a caspase inhibitor that can prevent apoptosis.The aims of this project were to evaluate the mechanism of the ZVAD inhibited EV-A71 virus and to provide experiment basis for finding new antiviral drugs.In this study,after treated with ZVAD in EV-A71 infected Vero cells,the viral replication was reduced,and the cell viability was higher than EV-A71 group.Additionally,ZVAD decreased the cell apoptosis and the level of inflammatory cytokines induced by EV-A71 in the infected Vero cells.ZVAD inhibited cell apoptosis by regulating ROS mediated signaling pathway and inflammation cytokines to achieve antiviral.
出处
《BIOCELL》
SCIE
2022年第4期1033-1039,共7页
生物细胞（英文）
基金
supported by the fund from Open Project of Guangdong Key Laboratory of Marine Materia Medica(LMM2020-7)
the fund from Guangzhou Institute of Pediatrics/Guangzhou Women and Children’s Medical Center(Nos.Pre-NSFC-2019-016,YIP-2019-059,IP-2019-019)
the Project of Traditional Chinese Medicine Bureau of Guangdong Province(No.20192075)
the technology planning projects of Guangdong province(No.202102010202)
The Guangdong Natural Science Foundation(2020A1515110648)
the Open Fund of Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications(2020A03).
