The effect of exosomes in transferring TET signaling alterations

Ten eleven translocation(TET)enzymes are composed of three representatives:TET1/2/3 which are involved in the hydroxymethylation of methylated cytosines.Because of the wide array of processes that are governed by these epigenetic marks,there have been a wide range of clinical effects associated with TET alterations.Even though many research groups have focused on analyzing the effect of TET alterations within certain cells,few have taken into consideration the effect of TET in the context of intercellular communication.One important entity through which intercellular communication occurs is represented by exosomes.Thus,in the current viewpoint we discussed the direct transfer of TET by exosomes,its alterations in the cell targeted by exosomes and the effect of TET alterations on exosome secretion.