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miR-153 as biomarker for cancer-functional role as tumor suppressor

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摘要 MicroRNA-153(miR-153),belongs toa dass of small non-coding RNA.It is a aritical regulator of gene expression at the post-transcriptional lewel which interacts with the functional mRNA at 3UTR rgion and suppresses the expression of the mRNA.More recently,it has become apparent that dhanges in the miR-153 axpression lead to invasion,metastasis,angiogenesis and various types of tumor progression.This review summarizes the connection between dysrgulation of miR-153 and various typas of cancer progression.miR-153 regulates various signaling pathways to inhibit the proliferation and induce apoptosis in the ancer cell and also show synergistic activity with anticancer drugs.In addition to this,the oncogenic bchavior of miR-153 and their use as a potential biomarker in cancer was also reviewed.
作者 SALONI THAKUR ADESH K.SAINI JOYDEEP DAS VIPIN SAINI PARIN BALHARA JAGPREET S.NANDA REENA V.SAINI
机构地区 Faculty of Applied Sciences and Biotechnology Department of Biotechnology Maharishi Markandeshwar University Department of Chemistry Department of Kinesiology Laboratory on the Mechanism and Regulation of Protein Synthesis
出处 《BIOCELL》 SCIE 2022年第1期13-26,共14页 生物细胞（英文）
关键词 BIOMARKER CANCER miR-153 Oncogenic Tumor suppressor
分类号 R73 [医药卫生—肿瘤]
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