Cannabis and male reproduction:Impact on offspring via sperm epigenome

Cannabis is the most widely used drug in theWestern societies particularly among adolescent and young adults.Epidemiological studies demonstrate that men use cannabis more frequently than women with higher risk in developing cannabis-related disorders.Although the direct adverse effects of cannabis on male reproductive functions have been studied both in humans and animal models,the possible long-term risks for the health of the users and their offspring are still an area of active research.