舒血宁联合静脉溶栓治疗急性脑梗死对患者血液流变学的影响

Impact of Shuxuening Combined with Intravenous Thrombolysis in the Treatment of Acute Cerebral Infarction on Patients’ Hemorheology

目的 探讨舒血宁联合静脉溶栓治疗急性脑梗死对患者血液流变学的影响。方法 196例急性脑梗死患者随机分为对照组(静脉溶栓)、舒血宁组(静脉溶栓+舒血宁注射液),比较两组的疗效、血液流变学和血清学指标、不良反应。结果 治疗后,舒血宁组的总有效率高于对照组,血浆黏度、全血高切黏度、全血低切黏度以及MMP-9、 CysC、 Hcy水平均低于对照组(P <0.05)。结论 舒血宁联合静脉溶栓治疗急性脑梗死可改善患者的血液流变学指标,下调血清MMP-9、 CysC、 Hcy水平。

Objective To explore the impact of Shuxuening combined with intravenous thrombolysis in the treatment of acute cerebral infarction on patients’ hemorheology.Methods 196 patients with acute cerebral infarction were randomly divided into the control group(intravenous thrombolysis) and the Shuxuening group(intravenous thrombolysis + Shuxuening injection).The efficacy,serological indicators,hemorheological indicators and adverse reactions were compared between the two groups.Results After treatment,the total effective rate in the Shuxuening group was higher than that in the control group,and the plasma viscosity,whole blood high shear viscosity and whole blood low shear viscosity,and the levels of MMP-9,Cys C and Hcy were lower than those in the control group(P <0.05).Conclusions Shuxuening combined with intravenous thrombolysis in the treatment of acute cerebral infarction can improve the hemorheological indicators of patients and down-regulate the levels of serum MMP-9,Cys C and Hcy.