血清OPG、TGF-β与急性心肌梗死患者介入治疗效果的相关性

Correlations of Serum OPG and TGF-β with the Effect of Interventional Therapy in Patients with Acute Myocardial Infarction

目的 分析血清骨保护素(OPG)、转化生长因子-β (TGF-β)与急性心肌梗死(AMI)患者介入治疗效果的关系。方法 选取273例行经皮冠状动脉介入治疗的AMI患者,统计治疗效果,收集患者的基线资料与实验室指标,分析血清OPG、TGF-β水平与AMI患者介入治疗效果的关系。结果 介入治疗后4周,273例AMI患者中治疗无效26例,占比9.52%。无效组的血清OPG水平高于有效组,血清TGF-β水平低于有效组(P <0.05);Logistic回归分析显示,OPG水平高是AMI患者介入治疗无效的危险因子(OR>1,P <0.05),TGF-β水平高是保护因子(OR<1,P <0.05)。结论 AMI患者的介入治疗效果与血清OPG水平、 TGF-β水平有关,临床可通过检测AMI患者的血清OPG、 TGF-β水平,预测介入治疗效果,指导治疗方案的实施。

Objective To analyze the correlations of serum osteoprotegerin(OPG) and transforming growth factor-β(TGF-β) with the effect of interventional therapy in patients with acute myocardial infarction(AMI).Methods 273 AMI patients who were treated with percutaneous coronary intervention were selected.The treatment effect was counted,and patients’ baseline data and laboratory indicators were collected.The correlations of serum OPG and TGF-β levels with the effect of interventional therapy in AMI patients were analyzed.Results 4 weeks after interventional treatment,26 of 273 AMI patients were ineffective,accounting for 9.52%.The serum OPG level in the ineffective group was higher than that in the effective group,while the serum TGF-β level was lower than that in the effective group(P 1,P<0.05),and high TGF-β level was a protective factor(OR <1,P <0.05).Conclusions The effect of interventional therapy in patients with AMI is related to the levels of serum OPG and TGF-β.Clinically,by detecting the levels of serum OPG and TGF-β in patients with AMI,the effect of interventional therapy can be predicted and the implementation of the treatment plan can be guided.