摘要
卵巢储备功能减退是导致女性不孕症的重要原因,针刺治疗该病疗效显著。本文从针刺调控PI3K/Akt、Nrf2/ARE、Bcl-2/Caspase-3等信号通路进行综述,对各通路的结构和信号转导、与卵巢储备功能的联系及针刺改善卵巢储备功能的相关研究3个方面进行归纳总结,以期为进一步探讨针刺改善卵巢储备功能的机制研究提供新思路,并为临床应用针刺治疗卵巢储备功能减退等生殖内分泌疾病提供依据。
Diminished ovarian reserve(DOR)is the main cause of female infertility.Acupuncture has a significant clinical effect on DOR.This article reviews the signal pathways,e.g.PI3K/Akt,Nrf2/ARE,Bcl-2/Caspase-3regulated with acupuncture in 3aspects,i.e.the structure and signal transduction of each pathway,the relationship with ovarian reserve and the improvement of acupuncture in ovarian reserve.It is anticipated to provide a new approach to further exploring the mechanism of acupuncture on the improvement of ovarian reserve.Moreover,the evidences of acupuncture may be obtained for its clinical treatment of DOR and other reproductive endocrine diseases.
作者
范素
房繄恭
FAN Su;FANG Yi-gong(Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《针刺研究》
CAS
CSCD
北大核心
2022年第7期644-648,共5页
Acupuncture Research
基金
国家自然科学基金项目(No.81674087)。
关键词
卵巢储备功能减退
早发性卵巢功能不全
卵巢早衰
针刺
信号通路
Diminished ovarian reserve
Premature ovarian insufficiency
Premature ovarian failure
Acupuncture
Signal pathways
