新型冠状病毒致COVID-19老鼠听力损伤

COVID-19 Resulting in Potential Hearing Damage of Rodents

目的:通过检测了小鼠和仓鼠体内ACE2和TMPRSS2的表达,找出感音神经性听力损失与新型冠状病毒肺炎之间的关系。方法:利用NCBI和GISAID的公开数据,评估了ACE2和TMPRSS2在金叙利亚仓鼠和小鼠大脑、内耳和肌肉中的转录组水平以及DNA和蛋白质水平。结果:在小鼠和仓鼠的DNA和转录组水平上鉴定了ACE2和TMPRSS2在内耳和大脑中的不同水平表达。大脑和内耳的蛋白质表达模式相似,而内耳的ACE2表达相对高于肌肉。结论:SARS 2019冠状病毒疾病显示出遗传性的潜在感染性,突发性耳聋可能是COVID-19无症状患者的特征。

Objectives To find out the association between the sensorineural hearing loss and coronavirus disease 2019(COVID-19),the expression of ACE2 and TMPRSS2 in hamsters and mice was detected.Design Using the public data from the National Center for Biotechnology Information and the Global Initiative on Sharing All Influenza Data,the expression of ACE2 and TMPRSS2 at the transcriptomic,DNA,and protein levels of ACE2 in the brain,inner ear,and muscle from the golden Syrian hamsters(Mesocricetus auratus)and mice(Mus musculus)was assessed.Results We identified ACE2 and TMPRSS2 expressed at different levels in the inner ear and brain at DNA and transcriptomic levels of both mice and hamsters.The protein expression from the brain and inner ear showed a similar pattern,while the expression of ACE2 from the inner ear was relatively higher than that from the muscle.Conclusion Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)shows genetic potential to infect the hearing system of rodents and lead to sudden sensorineural hearing loss that can be used as a characteristic to detect asymptomatic patients of COVID-19.