1例行根治性切除术的直肠癌患者术后并发切口感染和肺部感染的药物治疗分析

Analysis of Treatment of Postoperative Complications of Incisional Infection and Pulmonary Infection in a Patient with Rectal Cancer Undergoing Radical Resection

目的:分析1例行根治性切除术的直肠癌患者术后并发切口感染和肺部感染的药物治疗过程,为临床合理用药提供参考。方法:针对该例行根治性切除术的直肠癌患者术后并发的切口感染和肺部感染,临床药师通过分析患者当前病情和查阅相关文献资料,协助临床医生优化调整抗感染治疗方案和其他辅助治疗方案。结果:临床药师通过分析患者的微生物培养及其药敏试验结果,以及替加环素和头孢唑肟的抗菌作用特点,建议临床医生及时调整抗感染治疗方案以覆盖铜绿假单胞菌,同时优化营养支持方案和质子泵抑制剂的用药疗程,使得患者病情很快好转。结论:针对癌症术后这类重症患者并发的感染性疾病,临床药师尤其应当关注微生物培养及其药敏试验的结果,综合考虑抗菌药物的作用特点,协助临床医生制定科学合理的抗感染治疗方案,同时注意辅助支持治疗方案的优化,以确保患者治疗的成功。

Objective: To analyze the pharmacological treatment process of postoperative complications of incisional infection and pulmonary infection in a patient with rectal cancer undergoing radical resection, and provide reference for the rational use of clinical drugs. Methods: The clinical pharmacist, by analyzing the patient’s current condition and reviewing relevant literature, assisted the clinician in optimizing and adjusting the anti-infection treatment regimens and other adjuvant treatment regimens for the postoperative complications of incisional infection and pulmonary infection in the patient with rectal cancer undergoing radical resection. Results: By analyzing the patient’s microbiological culture and drug susceptibility test results, as well as the antibacterial action characteristics of tigecycline and ceftizoxime, the clinical pharmacist advised the clinician to adjust the anti-infection treatment regimens in a timely manner to cover Pseudomonas aeruginosa, and to optimize the nutrition support plan and medication courses of proton pump inhibitors,resulting in rapid improvement of the patient’s condition. Conclusion: For postoperative complications of infectious diseases in such cancer patients, the clinical pharmacist should pay particular attention to the results of microbiological culture and drug susceptibility tests, comprehensively consider the action characteristics of antibacterial drugs, and assist the clinician in formulating scientific and reasonable anti-infection treatment regimens, as well as optimize adjuvant supportive treatment regimens to ensure the success of patient treatment.