2011-2019年德宏傣族景颇族自治州吸毒人员HCV新发感染率及其影响因素

The incidence and risk factors of HCV infection among drug users in Dehong Dai and Jingpo autonomous prefectures,2011-2109

目的了解德宏傣族景颇族自治州(德宏州)吸毒人员HCV新发感染率及其影响因素。方法采用重复横断面的方法,HCV感染情况数据来自德宏州疾病预防控制中心自建的“HIV数据库系统”吸毒人群数据库模块,采用发病密度计算HCV新发感染率,Cox比例风险模型分析HCV新发感染的影响因素。结果共3400例至少随访一次对象纳入分析。2011-2019年共累积随访6498.9人年,期间351例(10.3%)发生HCV阳转,新发感染率为5.3/100人年。Cox比例风险模型多因素分析结果显示,未婚、注射吸毒但不共用针具和注射吸毒且共用针具、基线HIV抗体检测阳性者新发HCV感染风险分别显著高于在婚者、无注射吸毒史和基线HIV抗体检测阴性者(a HR=1.35,95%CI:1.08~1.69;a HR=5.43,95%CI:4.17~7.18,a HR=4.90,95%CI:3.13~7.66;a HR=2.97,95%CI:2.10~4.21)。结论2011-2019年德宏州吸毒人员HCV新发感染率较高,尤其应关注有注射吸毒、共用针具史和HIV阳性吸毒人员的HCV感染风险。

Objective To investigate the incidence and risk factors of HCV infection among drug users in Dehong Dai and Jingpo Autonomous Prefecture.Methods Using a repeated cross-sectional design,data on HCV infection was derived from Drug Users Database Module under HIV Database System built by Dehong CDC.Incidence density was calculated.The Cox proportional-hazards model explored the risk factors of incident HCV infections.Results 3 400subjects with at least one follow-up visit were included.During 6 498.9 person-years of follow-up,351(10.3%) subjects were infected with HCV with the incidence density of 5.3 per 100 person-years.Multivariable Cox regression analysis indicated that being unmarried(a HR=1.35,95%CI:1.08-1.69),history of injection drug use but no needles syringe sharing (a HR=5.43,95%CI:4.17-7.18),history of injection drug use and sharing needles syringes(a HR=4.90,95%CI:3.13-7.66),HIV infection(a HR=2.97,95%CI:2.10-4.21) were significantly associated with HCV infections,respectively.Conclusions The incidence of HCV infection among drug users in Dehong Prefecture is high.Particular attention should be paid to those with a history of injection drug use,needle/syringe sharing,and HIV infection.