Ph^(-)骨髓增殖性肿瘤患者血栓形成的研究进展

Research progress on thrombosis of Philadelphia-negative myeloproliferative neoplasms

Ph-骨髓增殖性肿瘤(MPN)是一种造血干细胞恶性克隆性疾病,表现为一系或多系髓系细胞克隆性增殖。血栓形成是影响MPN患者生存的主要并发症及导致其死亡的原因。影响MPN患者血栓形成的危险因素包括高龄、男性、血栓形成史、白细胞计数增高、血细胞比容(HCT)增高、合并心血管疾病危险因素,以及伴MPN驱动及伴随基因突变等。笔者拟就MPN患者血栓形成的危险因素及机制进行综述,旨在为Ph-MPN患者的血栓防治提供理论依据。

Philadelphia-negative(Ph-)myeloproliferative neoplasms(MPN)is a malignant clonal disease of hematopoietic stem cells,manifested by clonal proliferation of myeloid cells in one or multiple lines.Thrombosis is the main complication affecting survival of patients with MPN which can lead to death.The risk factors affecting thrombosis in MPN patients include aged,male,history of thrombosis,increased white blood cell count and hematocrit(HCT),combined with cardiovascular disease risk factors,and genetic mutations of MPN driver genes and concomitant genes.This paper intends to review these risk factors and mechanisms of thrombosis in patients with MPN,aiming to provide a theoretical basis for the prevention and treatment of thrombosis in patients with Ph-MPN.