CD8^(+)T细胞应答在慢性乙肝肝损伤中的作用和机制

The role of CD8^(+)T cell response in the liver injury during chronic hepatitis B

CD8+T细胞应答在慢性乙肝感染中具有至关重要的地位。有缺陷的HBV特异性CD8^(+)T细胞应答常常导致感染控制不力,而旁观者CD8^(+)T细胞应答和肝内浸润则可能通过抗原不依赖的方式促进肝细胞发生损伤。肝血窦内的血小板聚集促进CD8^(+)T细胞锚定于肝内,使CD8^(+)T细胞在肝内缓慢爬行,识别抗原,导致肝细胞特异性或非特异性损伤。本文综述了近来肝内HBV特异性和旁观者CD8^(+)T细胞应答在慢性乙肝相关肝损伤发生中的研究进展。

The CD8^(+)T cell responses play a crucial role in chronic hepatitis B infection.Defective HBVspecific CD8^(+)T cell responses often lead to ineffective control of HBV infection,whereas bystander CD8^(+)T cell responses and intrahepatic infiltration may contribute to hepatocyte injury.Platelet aggregation within the hepatic sinuses anchors CD8^(+)T cells within the liver,allowing CD8^(+)T cells to crawl slowly in the liver and recognize antigens,which subsequently leads to hepatocyte death in antigen-dependent or independent manner.This review summarizes the activation mechanisms of intrahepatic HBV-specific CD8^(+)T cell and roles of bystander CD8^(+)T cell responses in chronic hepatitis B-related liver damage.