WSB2在宫颈癌中的表达及其与临床相关性

CORRELATIONS BETWEEN EXPRESSION OF WSB2 IN CERVICAL CANCER AND MICROVESSEL DENSITY

目的 本研究旨在检测信号传导抑制蛋白WD重复蛋白2(WSB2)在宫颈癌组织中的表达及其与临床病理参数的关系,并且分析与微血管密度(MVD)的相关性,探讨它们与宫颈癌发生发展的可能关系。方法通过免疫组织化学染色法检测华北理工大学附属医院70例宫颈癌组织标本WSB2表达情况及其与临床病理参数之间的相关性,并进行MVD测定,分析WSB2表达与MVD的关系。另选宫颈上皮内病变组织30例和正常组织15例作为对照。结果 与正常组、良性组、癌组相比较,WSB2蛋白在70例宫颈癌组织中的阳性表达率高,为88.6%,在正常和良性组织表达率低,分别为13.3%和25.7%,差异有统计学意义(P<0.05),WSB2在宫颈癌的表达与患者年龄、病理分级、组织分型差异无统计学意义(P>0.05),与淋巴结转移和FIGO分期的进展表达量显著升高(P<0.05);MVD在宫颈癌的表达与临床分期、病理分级和淋巴结转移呈正相关,与年龄、组织分型差异无统计学意义(P>0.05)。结论 在宫颈癌组织中WSB2高表达,与分化程度和临床分期相关,提示WSB2可能与宫颈癌的发生发展有一定关联,将来可以作为宫颈癌的生物分子标记物。

Objective To detect the relationships and expression of a member of the WD repeat protein subfamily(WSB2)in cervical cancer tissues and microvessel density.To explore their possible relationship to the occurrence and progression of cervical cancer cells.Methods The expression of WSB2 in cancer tissue specimens of seventy cervical cancer patients from the Affiliated Hospital of North China University of Science and Technology were detected by immunohistochemistry,and the correlation between them in clinical and pathological parameters was analyzed.The value of MVD were detected and the relationships between the expressions of WSB2,the value of MVD were analyzed,30 cases of cervical intraepithelial neoplasia and 15 cases of normal tissue were selected as controls.Results Compared with the normal groups,benign groups and cancer groups,WSB2 protein was positive rate 88.6% in 70 cases of cervical cancer tissue,which was significantly higher than that in the normal group13.3% and benign group 26.7%(P0.05),but increased significantly with lymphatic metastasis、the progression of stage(P0.05).Conclusion WSB2 is over-expressed in cervical cancer tissues,it’s correlated with the degree of differentiation and clinical stage,WSB2 is closely related to the occurrence and development of cervical cancer,which can be used as the biomarkers of cervical cancer.