不同程度肺功能改变的哮喘儿童规范治疗效果

Curative Effect of Asthma Children with Varying Degrees of Pulmonary Function Changes after Standard Treatment

目的分析不同程度肺功能患儿进行舒利迭药物规范治疗的效果。方法选取本院接收治疗的150例支气管哮喘患儿作为本研究对象,根据肺疾病严重程度将其分为5组,分别为一组(混合性通气功能障碍组)、二组(重度阻塞性通气功能障碍组)、三组(中度阻塞性通气功能障碍组)、四组(轻度阻塞性通气功能障碍组)、五组(小气道功能障碍组),每组30例。比较各组治疗前及治疗1个月的肺功能情况:用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))、第1秒最大呼气率(FEV_(1)/FVC%)、最大呼气峰流速(PEF)、用力呼气中段流速(FEF_(25%~75%))、用力呼气25%流速(FEF_(25%))、用力呼气50%流速(FEF_(50%))、用力呼气75%流速(FEF_(75%));分析、观察疗效,评估各组患者改善后肺功能是否存在差异。结果治疗1个月后,各组患儿的FVC、FEV_(1)、FEV_(1)/FVC%、FEF_(25%)、FEF_(50%)、FEF_(75%)、FEF_(25%~75%)值均存在不同程度的增加(P<0.05)。各组患儿的FVC、FEV_(1)、FEV_(1)/FVC%、FEF_(25%)、FEF_(50%)、FEF_(75%)、FEF_(25%~75%)值随着疾病的严重程度的加重而降低,且利用统计软件做统计分析差异有统计学意义(P<0.05),进行两两比较各组之间的差异发现疾病程严重度越高肺功能改善越不显著。结论规范治疗能提高不同程度肺功能支气管哮喘患儿的疗效,且效果显著。但随着疾病严重程度的加重,规范治疗对于肺功能的改善效果越不显著,临床应尽早规范治疗管理。

Objective To analyze the efficacy of Seretide in children with different degrees of pulmonary function.Methods A total of 150 children with bronchial asthma treated in our hospital were divided into 5 groups according to the severity of pulmonary function.They were divided into five groups:mixed ventilatory dysfunction group,severe obstructive ventilatory dysfunction group,moderate obstructive ventilatory dysfunction group,mild obstructive ventilatory dysfunction group and small airway dysfunction group.There were 30 cases in each group.The pulmonary function of each group was compared before treatment and 1 month after treatment:FVC,FEV_(1),FEV_(1)/FVC%,PEF,FEF_(25%~75%),FEF_(25%),FEF_(50%)and FEF_(75%).Analyze and observe the curative effect,and evaluate whether there is difference in lung function after improvement in each group.Results After one month of treatment,the values of FVC,FEV_(1),FEV_(1)/FVC%,FEF_(25%),FEF_(50%),FEF_(75%)and FEF_(25%~75%)in each group increased in different degrees(P<0.05).The values of FVC,FEV_(1),FEV_(1)/FVC%,FEF_(25%),FEF_(50%),FEF_(75%)and FEF_(25%~75%)in each group decreased with the aggravation of the severity of the disease,and the difference was statistically significant by statistical software(P<0.05).It was found that the higher the severity of the disease,the less significant the improvement of lung function.Conclusion Standardized treatment can improve the curative effect of bronchial asthma in children with different degrees of pulmonary function,but with the aggravation of the severity of the disease,the effect of standardized treatment on the improvement of pulmonary function is less obvious,clinical management should be standardized as soon as possible.