左西孟旦治疗心力衰竭的疗效评价

Evaluation of the efficacy of levosimendan in the treatment of heart failure

目的评价左西孟旦治疗心力衰竭的临床疗效。方法70例心力衰竭患者,随机分为对照组与观察组,各35例。对照组给予单纯常规药物治疗,观察组给予左西孟旦联合常规药物治疗。比较两组治疗前后心功能指标[左室射血分数(LVEF)、B型尿钠肽(BNP)]改善情况及治疗效果。结果治疗后,观察组LVEF(68.67±5.70)%高于对照组的(52.66±4.73)%,BNP(88.51±2.34)ng/L低于对照组的(110.24±4.05)ng/L,差异均有统计学意义(P<0.05)。观察组治疗总有效率97.14%高于对照组的82.86%,差异有统计学意义(P<0.05)。结论左西孟旦治疗心力衰竭的临床疗效显著,可以有效改善患者心功能水平,是一种有效、可靠的治疗药物,值得临床推广应用。

Objective To evaluate the clinical efficacy of levosimendan in the treatment of heart failure.Methods A total of 70 patients with heart failure were randomly divided into the control group and the observation group,with 35 cases in each group.The control group was treated with conventional drug treatment alone,while the observation group was treated with levosimendan combined with conventional drug treatment.The improvement of cardiac function indexes[left ventricular ejection fraction(LVEF),B-type natriuretic peptide(BNP)]before and after treatment and the therapeutic effect were compared between the two groups.Results After treatment,the LVEF(68.67±5.70)% of the observation group was higher than(52.66±4.73)% of the control group,and the BNP(88.51±2.34)ng/L was lower than(110.24±4.05)ng/L of the control group.All the differences were statistically significant(P<0.05).The total effective rate 97.14% of the observation group was higher than 82.86% of the control group,and the difference was statistically significant(P<0.05).Conclusion The clinical effect of levosimendan in the treatment of heart failure is remarkable,which can effectively improve the cardiac function of patients.It is an effective and reliable treatment drug,and it is worthy of clinical promotion and application.