布拉氏酵母菌联合乳果糖治疗糖尿病便秘的临床研究

Clinical study of Saccharomyces boulardii combined with lactulose in the treatment of diabetic constipation

目的探讨布拉氏酵母菌联合乳果糖治疗糖尿病便秘的临床效果。方法60例糖尿病便秘患者为研究对象,根据随机分组原则分为治疗组及对照组,每组30例。治疗组患者应用布拉氏酵母菌联合乳果糖治疗,对照组患者单纯应用布拉氏酵母菌治疗。比较两组临床治疗效果、不良反应发生情况及治疗前后临床症状积分。结果治疗组患者总有效率为93.33%,高于对照组的73.33%,差异具有统计学意义(P<0.05)。治疗后,两组患者排便时间、排便次数、大便形状、排便难度积分均较本组治疗前降低,且治疗组排便时间、排便次数、大便形状、排便难度积分分别为(0.91±0.17)、(0.83±0.12)、(0.82±0.13)、(0.95±0.14)分,低于对照组的(1.24±0.21)、(1.25±0.18)、(1.13±0.17)、(1.32±0.18)分,差异具有统计学意义(P<0.05)。治疗组不良反应发生率6.67%低于对照组的26.67%,差异具有统计学意义(P<0.05)。结论布拉氏酵母菌联合乳果糖治疗糖尿病便秘效果显著,能有效改善患者排便困难等临床症状,排便时间和次数逐渐规律,不良反应发生率低,安全性较高,有利于增强糖尿病患者胃肠道功能,促进排便正常,故而值得在临床大力推广和应用。

Objective To discuss the clinical effect of Saccharomyces boulardii combined with lactulose in the treatment of diabetic constipation.Methods A total of 60 patients with diabetic constipation were selected as the research subjects,and were randomly divided into treatment group and control group,with 30 cases in each group.Patients in the treatment group were treated with Saccharomyces boulardii combined with lactulose,and patients in the control group were treated with Saccharomyces boulardii alone.The clinical effect,occurrence of adverse reactions and clinical symptom scores before and after treatment were compared between the two groups.Results The total effective rate in the treatment group was 93.33%,which was higher than 73.33% in the control group,and the difference was statistically significant(P<0.05).After treatment,the defecation time,defecation frequency,stool shape and defecation difficulty score of the two groups were all decreased compared with those of this group before treatment,and the defecation time,defecation frequency,stool shape and defecation difficulty score of the treatment group were(0.91±0.17),(0.83±0.12),(0.82±0.13),and(0.95±0.14)points,which were lower than(1.24±0.21),(1.25±0.18),(1.13±0.17),and(1.32±0.18)points of the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions 6.67% in the treatment group was lower than 26.67% in the control group,and the difference was statistically significant(P<0.05).Conclusion Saccharomyces boulardii combined with lactulose is effective in the treatment of diabetic constipation,which can effectively improve the clinical symptoms of difficult defecation,the time and frequency of defecation are gradually regular,the incidence of adverse reactions is low,and the safety is high.It is conducive to enhancing the function of the gastrointestinal tract of diabetes mellitus patients and promoting normal defecation,and is worthy of vigorous promotion and application in clinical practice.