bFGF在皮肤慢性溃疡修复中的研究进展

Research Progress of bFGF in the Repair of Chronic Skin Ulcer

皮肤慢性溃疡创面是指无法正常有序和及时的修复或不能恢复正常的解剖和功能的创面。其根据病因可分为压迫性、糖尿病相关性、血管性以及创伤性创面等。在某些条件下,创面的组织修复细胞发生过度凋亡,导致创面愈合阶段病程较长、愈合过程产生障碍,是某些慢性难愈合创面的发病机制之一。bFGF是目前已知生长因子中最强的促细胞生成因子。现主要论述bFGF在皮肤慢性溃疡创面修复中的研究进展,旨在为相关研究提供参考。

Chronic skin ulcer woundsrefer to woundsthat cannot be repaired in an orderly and timely manner or can not restore normal anatomy and function.According to the etiology, it can be divided into compressive, diabetes-related, vascular, and traumatic wounds.Under some conditions, excessive apoptosis occurs in the tissue repair cells of the wound, leading to a long course of disease and obstacles in the healing process, which is one of the pathogenesis of some chronic refractory wounds. Basic fibroblast growth factor (bFGF) is the strongest pro-cytokine among the known growth factors.In order to provide reference for related research,this paper mainly discusses the research progress of bFGF in the repair of skin chronic ulcer wounds.