促分裂原活化的蛋白激酶信号通路与能量代谢的关系

Relation between MAPK Pathway and Energy Metabolism

能量代谢每时每刻都伴随着物质代谢在生命体内发生。生物通过利用物质代谢产生的高能磷酸化合物以维持各项生命功能的运转,不同状态下的细胞通过利用各种物质通过不同的通路进行不同的代谢方式。促分裂原活化的蛋白激酶(MAPK)通路作为生命体里广泛存在的一类信号蛋白,影响着细胞、生物体的生命活动。MAPK通路在能量代谢的各个环节起着非常重要的作用。通过研究MAPK通路中的胞外信号调节激酶(ERK)通路、Jun激酶(JNK)通路、P38通路均与能量代谢有关的蛋白、靶点、关键酶、转运体,与三大营养物质能量代谢相结合,从而为能量代谢相关的细胞功能进一步研究铺垫,并为今后治疗肿瘤性疾病、感染性疾病、代谢性疾病等提供新思路。

Energy metabolism happens constantly in the body along with material metabolism.As a result of material metabolism,organisms produce high-energy phosphoric acid compounds to support a variety of life processes.By utilizing diverse chemicals through various pathways,cells in various states carry out distinct metabolisms.Mitogen-activated protein kinase(MAPK)pathway,a type of signal protein that is commonly present throughout life,affects a variety of cellular and organismal functions.In all facets of energy metabolism,the MAPK pathway is critical.This study investigated proteins,targets,significant enzymes,and transporters in the energy metabolism-relevant extracellular signal-regulated kinase(ERK),c-Jun N-terminal kinase(JNK),and P38 pathways in the MAPK pathway,as well as their interaction with the energy metabolism of the three major nutrients,to open the door for further investigation into cellular processes related to energy metabolism and offer fresh suggestions for the treatment of tumor diseases,infectious diseases,and other conditions.