泮托拉唑与枸橼酸铋钾联合治疗胃溃疡的应用价值

Effect of Pantoprazole Combined with Bismuth Potassium Citrate on Gastric Ulcer

目的探讨泮托拉唑与枸橼酸铋钾联合治疗胃溃疡的应用价值。方法选2018年9月至2019年9月在本院治疗的胃溃疡患者80例,按照来院先后顺序分组,对照组40例,单独采用枸橼酸铋钾治疗,观察组40例,采用泮托拉唑与枸橼酸铋钾联合治疗。对比两组临床治疗效果、用药不良反应发生率、生活质量评分(SF-36)以及各实验室指标水平。结果经治疗,观察组临床治疗有效率为97.50%,对照组临床治疗有效率为80.00%,两组差异明显(P<0.05);观察组用药不良反应发生率为5.00%,对照组用药不良反应发生率为25.00%,两组差异明显(P<0.05);治疗前,观察组与对照组生活质量各项评分无明显差异性(P>0.05),治疗后,观察组生活质量各项评分明显高于对照组(P<0.05)。治疗前,两组IL-6、CRP、PCT、AMS、D-二聚体水平相似,差异无显著性,P>0.05;治疗后,研究组IL-6、CRP、PCT、AMS、D-二聚体均低于对照组,差异显著,P<0.05。结论使用泮托拉唑与枸橼酸铋钾联合治疗胃溃疡,药物疗效相较于单一用药显著提升,药物安全性良好,可改善患者生活质量。

Objective To investigate the effect of pam Tora and potassium bismuth citrate on gastric ulcer.Methods 80 patients with gastric ulcer treated in our hospital from September 2018 to September 2019 were divided into control group and 40 patients were treated with bismuth potassium citrate alone 40 case in the observation group were treated with pantoprazole and bismuth potassium.Comparison of the two groups of clinical treatment,the incidence of adverse drug reactions,the quality of life of patients score(SF-36)and the level of each laboratory index.Results The effective rate of clinical treatment in observation group was 97.50% and that in control group was 80.00% The difference between the two groups was significant(P<0.05);the incidence of adverse drug reactions in the observation group was 5.00%,the incidence of adverse drug reactions in the control group was 25.00%,and the difference between the two groups was significant(P<0.05);before treatment,there was no significant difference in the quality of life score between the observation group and the control group(P>0.05).After theat ment,the scores of quality of life in the observation group was significantly higher than those in the control group(P<0.05).Before treatment,the levels of IL-6,CRP,PCT,AMS,D-dimer in the two groups were similar,with no significant difference,P>0.05;after treatment,the levels of IL-6,CRP,PCT,AMS,D-dimer in the study group were similar the aggregates were lower than the control group,the difference was significant,P<0.05.Conclusion The combination of pam Tora and bismuth potassium citrate in the treatment of gastric ulcer is more effective than single drug.