泮托拉唑与奥美拉唑联合生长抑素治疗肝硬化患者上消化道大出血的临床效果

Clinical Effect of Pantoprazole and Omeprazole Combined with Somatostatin in the Treatment of Upper Gastrointestinal Hemorrhage in Patients with Liver Cirrhosis

目的分析泮托拉唑、奥美拉唑、生长抑素对肝硬化患者上消化道大出血的治疗效果。方法选取2018年3月至2019年11月本院收治的120例肝硬化上消化道大出血患者纳入本次研究样本中,以随机抽样法分成对照组与试验组,对照组60例,试验组60例。两组患者皆采取基础治疗,在此基础上,对照组采用奥美拉唑联合生长抑素进行治疗,试验组采用泮托拉唑联合生长抑素进行治疗,对比两组患者治疗前后的门静脉血流量、脾静脉血流量、输血量、止血耗时、症状改善耗时、住院耗时、治疗有效率、不良反应发生率。结果治疗前,两组患者脾静脉血流量、门静脉血流量比较无统计学意义(P>0.05);治疗后,两组患者脾静脉血流量、门静脉血流量相比治疗前较低,前后对比差异具有统计学意义(P<0.05),但试验组脾静脉血流量、门静脉血流量对比对照组无统计学意义(P>0.05)。试验组患者的输血量、止血耗时、症状改善耗时、住院耗时相比于对照组无统计学意义(P>0.05)。试验组治疗有效率为90.00%,与对照组治疗有效率(88.33%)对比,不具有统计学对比意义(P>0.05)。试验组不良反应发生率为10.00%,相比对照组不良反应发生率(11.67%)低,但对比结果无明显统计学意义(P>0.05)。结论针对肝硬化上消化道大出血患者采取泮托拉唑与奥美拉唑联合生长抑素进行治疗均取得了良好的治疗效果,且不良反应发生率降低,临床相关指标得到改善,可根据实际情况选择适合患者的方案。

Objective To analyze the therapeutic effects of pantoprazole,omeprazole and somatostatin on upper gastrointestinal hemorrhage in patients with liver cirrhosis.Methods A total of 120 patients with upper gastrointestinal hemorrhage due to liver cirrhosis treated in our hospital from March 2018 to November 2019 were selected and included in the study sample.They were randomly divided into control group and test group,with 60 cases in the control group and 60 cases in the test group.Both groups of patients were treated with basic treatment.On this basis,the control group was treated with omeprazole combined with somatostatin,and the experimental group was treated with pantoprazole combined with somatostatin.The portal vein blood flow,splenic vein blood flow,blood transfusion volume,hemostasis time,symptom improvement time,hospitalization time,treatment efficiency and adverse reaction rate of the two groups were compared before and after treatment.Results Before treatment,there was no significant difference in the indexes of portal vein blood flow and splenic vein blood flow between the two groups(P>0.05);after treatment,the portal vein blood flow and splenic vein blood flow of the two groups were lower than those before treatment,and the difference was statistically significant(P<0.05).The portal vein blood flow and splenic vein blood flow of the test group were not statistically significant compared with those of the control group(P>0.05).Compared with the control group,the amount of blood transfusion,hemostasis time,symptom improvement time and hospitalization time in the test group were not statistically significant(P>0.05).The effective rate of the test group was 90.00%,which was not statistically significant(P>0.05)compared with 88.33%of the control group.The incidence of adverse reactions in the test group was 10.00%,which was lower than that in the control group(11.67%),and the comparison results had no significant statistical significance(P>0.05).Conclusion Pantoprazole and omeprazole combined with somatostatin in the treatment of patients with upper gastrointestinal hemorrhage due to liver cirrhosis have achieved good therapeutic effects,and the incidence of adverse reactions has been reduced,and the clinical related indicators have been improved.The scheme suitable for patients can be selected according to the actual situation.