放化疗性口腔黏膜炎动物模型的研究进展与比较

Research progress and comparison of the establishment of animal models of radiotherapy or chemotherapy-induced oral mucositis

放化疗性口腔黏膜炎目前机制尚未明确,为进一步研究需构建相应的动物模型、系统总结造模方法,本研究检索了Web of Science、Pubmed、CNKI数据库2015年1月~2021年1月发表的进行放化疗性口腔黏膜炎动物研究的文献并进行对比分析。实验动物包括:金黄地鼠、小鼠、大鼠、豚鼠、小型猪;造模方法可分类为:化疗模型、化疗联用局部刺激模型、放疗模型、放疗联用局部刺激模型、放化疗联用模型。本研究对各种造模方法的长处与不足进行分析,供后续研究参考。

The mechanism of radiotherapy or chemotherapy-induced oral mucositis is not yet clear.And model establishment is needed in further study.In order to summarize the methods of model establishment and make a comparison,literature databases including Web of Science,Pubmed and CNKI were searched for related researches from January 2015 to January 2021.Hamsters,mice,rats,guinea pigs and miniature pigs were chosen to be modeling animals and modeling methods could be classified into:chemotherapy,chemotherapy combined with superficial mucosal irritation,radiotherapy,radiotherapy combined with superficial mucosal irritation and chemoradiotherapy.Advantages and disadvantages had been analyzed in this study to provide reference for following studies.