接触蛋白1与恶性肿瘤

CNTN-1 protein and malignant tumors

接触蛋白1(contactin 1,CNTN-1)是免疫球蛋白超家族成员之一,属于糖基酰肌醇锚定的神经细胞黏附因子。CNTN-1在胃癌、肺癌、甲状腺癌、食管鳞癌、宫颈癌等恶性肿瘤中表达增加,且与上述癌症患者肿瘤细胞发展、浸润和转移密切相关。目前,CNTN-1蛋白在恶性肿瘤疾病发展中的作用及其作用机制研究甚少。本文对近年关于CNTN-1蛋白在癌症中表达、作用与作用机制、预后的相关研究进展做一综述。

Contactin 1(CNTN-1)is a member of the immunoglobulin superfamily and belongs to the nerve cell adhesion molecule anchored by glycosyl phosphatidylimosita.More and more reports indicate that CNTN-1 is up-regulated in gastric cancer,lung cancer,thyroid cancer,esophageal squamous cell carcinoma,cervical cancer and other malignant tumors,and is closely related to the disease development,invasion and metastasis of the above-mentioned tumor patients.However,there are few studies on the role of CNTN-1 protein in the occurrence,development,metastasis,and invasion of malignant tumors and its related mechanisms.The following is a summary of the recent progress in research on the role of CNTN-1 protein in cancer and its related mechanisms.