高密度脂蛋白与急性脑梗死动脉溶栓术后缺血再灌注的相关性分析

Correlation analysis of high-density lipoprotein and ischemia-reperfusion after arterial thrombolysis in acute cerebral infarction

目的:分析高密度脂蛋白(HDL)与急性脑梗死(ACI)动脉溶栓术后缺血再灌注的相关性。方法:选择神经科诊治的急性脑梗死患者84例为研究对象,所有患者均给予动脉溶栓术治疗,检测高密度脂蛋白表达水平,判定缺血再灌注发生情况并进行相关性分析。结果:所有患者完成动脉溶栓术,发生缺血再灌注14例(再灌注组),发生率为16.7%。再灌注组的血浆高密度脂蛋白含量低于非再灌注组,差异有统计学意义(P<0.05)。再灌注组的白细胞计数、中性粒细胞计数、单核细胞计数高于非再灌注组,差异有统计学意义(P<0.05),两组血小板、血红蛋白对比差异无统计学意义(P>0.05)。在84例患者中,Spearman相关分析显示高密度脂蛋白、白细胞计数、中性粒细胞计数、单核细胞计数与缺血再灌注存在相关性,差异有统计学意义(P<0.05)。非条件Logistic回归分析显示高密度脂蛋白、白细胞计数、中性粒细胞计数、单核细胞计数都为导致缺血再灌注发生的重要因素,差异有统计学意义(P<0.05)。结论:急性脑梗死动脉溶栓术后缺血再灌注比较常见,高密度脂蛋白与缺血再灌注存在相关性,也是导致缺血再灌注发生的重要因素。

Objective To explore and analysis the correlation between high-density lipoprotein(HDL) and acute cerebral infarction(ACI) arterial thrombolysis after ischemia-reperfusion.Method A total of 84 patients with acute cerebral infarction who were diagnosed and treated in the Department of Neurology of our hospital were selected as the research objects.All patients were treated with arterial thrombolysis,and the expression level of high-density lipoprotein were detected to determine ischemia.The occurrence of ischemia-reperfusion were recorded and given correlation analysis.Results All patients were completed arterial thrombolysis,there were 14 cases of ischemia-reperfusion occurred(reperfusion group),the incidence were 16.7%.The plasma high-density lipoprotein content of the reperfusion group were lower than that of the non-reperfusion group(P<0.05).In the 84 patients,Spearman correlation analysis showed that high-density lipoprotein,white blood cell count,neutrophil count,monocyte count were correlated to the ischemia-reperfusion(P<0.05).Unconditional Logistic regression analysis showed that high-density lipoprotein,white blood cell count,neutrophil count,monocyte count were all important factors leaded to ischemia-reperfusion(P<0.05).Conclusion Ischemia-reperfusion are common after arterial thrombolysis in acute cerebral infarction.There are correlation between high-density lipoprotein and ischemia-reperfusion,which are also important factor leading to ischemia-reperfusion.