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早期使用沙库巴曲缬沙坦治疗急性失代偿心力衰竭患者的临床研究 被引量:2

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摘要 目的:探讨早期使用沙库巴曲缬沙坦(ARNI)治疗急性失代偿心力衰竭(ADHF)患者的临床疗效。方法:选取心内科诊断为ADHF的84例患者为研究对象,待血流动力学稳定后根据数字奇偶法分为对照组和观察组,各42例。对照组给予血管紧张素转化酶抑制剂治疗,观察组给予ARNI治疗,均连续治疗1个月,比较两组患者临床疗效,用药前后左心室射血分数(LVEF)、左室收缩末内径(LVESD)及左室舒张末内径(LVEDD)、心率和收缩压变化情况,记录两组患者用药期间不良反应发生情况。结果:用药后观察组治疗总有效率高于对照组(88.10%vs 69.05%,χ^(2)=4.525,P=0.033);用药后两组患者LVEF、LVESD以及LVEDD心功能指标较治疗前均有所改善,且观察组左心功能指标改善程度优于对照组,差异均有统计学意义(P<0.05);用药后两组患者心率、收缩压水平均明显下降,且观察组心率、收缩压水平下降更显著,差异均有统计学意义(P<0.05);两组患者用药期间症状性低血压、高钾血症、肾功能恶化等不良反应总发生率比较,差异无统计学意义(16.67%vs 11.90%,χ^(2)=0.389,P=0.533)。结论:血流动力学稳定后早期使用ARNI治疗ADHF患者疗效显著,能明显改善心功能,安全性较高。
作者 关丽丽
出处 《吉林医学》 CAS 2022年第8期2172-2174,共3页 Jilin Medical Journal
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