miRNA在气道重构中的研究进展

Research progress on miRNA in airway remodeling

气道重构是指气道组织由于反复慢性炎症刺激损伤及不全性修复所导致的结构功能变化,多见于哮喘、COPD等慢性气道炎症性疾病,是导致气道不可逆性狭窄和气流受限的重要原因。微RNA(miRNA)参与人体几乎所有的病理生理过程,是功能优异的基因调控因子。近年,研究者发现miRNA通过不同的通路和靶点影响气道平滑肌细胞的增殖和迁移、上皮细胞的增殖和黏附、成纤维细胞增生、气道血管生成、杯状细胞的分泌和气道炎症的发生,从而影响气道重构。该文就miRNA在气道重构中的研究进展进行综述。

Airway remodeling refers to the structural and functional changes of airway tissues caused by repeated chronic inflammatory stimulation injury and incomplete repair.It is commonly seen in chronic airway inflammatory diseases,such as asthma and COPD,which is an important cause of irreversible airway stenosis and restricted airflow.MicroRNA(miRNA)molecules are involved in almost all pathophysiological processes in the human body,and they are excellent functional gene regulators.Recent studies have found that miRNA affects airway smooth muscle cell proliferation and migration,epithelial cell proliferation and adhesion,fibroblast proliferation,airway angiogenesis,goblet cell secretion and airway inflammation through different pathways and targets,thus further affecting airway remodeling.In this article,the research progresses on miRNA in airway remodeling were reviewed.