高病毒载量慢性乙型肝炎抗病毒治疗研究进展

Research progress on anti-viral treatment for chronic hepatitis B patients with high viral load

慢性乙型肝炎(CHB)是一种严重危害人类健康的疾病。HBV复制是CHB患者发病的主要原因,高病毒载量是其发展为肝硬化或肝细胞癌的高危因素,抗病毒治疗在高病毒载量CHB患者治疗中发挥重要作用。临床上高病毒载量CHB患者存在病毒学应答率偏低的现象,其抗病毒治疗方案是近年来临床研究的热点和难点。该文综述了高病毒载量CHB抗病毒治疗的研究进展。

Chronic hepatitis B(CHB)is a severe disease that affects human health.Replication of hepatitis B virus(HBV)is the main cause of morbidity in CHB patients.High viral load is a high-risk factor for CHB progressing into liver cirrhosis or hepatocellular carcinoma.Anti-viral therapy plays a significant role in the treatment of CHB patients with high viral load.In clinical practice,CHB patients with high viral load yield low virological response rate.In recent clinical trials,anti-viral therapy has become the hotspot and challenge.In this article,research progresses on anti-viral therapy for CHB patients with high viral load were reviewed.