白介素在慢性疼痛的产生和维持中的作用

The role of interleukin in the generation and maintenance of chronic pain

慢性疼痛已经成为全世界普遍关注的健康问题之一,荟萃分析发现不分种类的慢性疼痛在中、低收入国家中发病率约56%,且呈逐年增长趋势,给患者和社会带来了极大的医疗负担。关节炎、癌症、糖尿病性神经疾病、创伤后遗症、炎性肠病等疾病均合并不同程度的慢性疼痛。在慢性疼痛的发病机理中,白介素介导的中枢神经系统炎症和外周伤害感受器敏化作用至关重要。该文将总结近年来白介素和慢性疼痛的研究进展,为慢性疼痛治疗提供新的策略和靶标。

Chronic pain has become one of the health problems of universal concern in the world. Meta-analysis found that the incidence of chronic pain of all kinds in middle-and low-income countries is about 56%, and it shows an increasing trend year by year, bringing enormous medical burden to patients and society. Arthritis, cancer,diabetic neuropathy, traumatic sequelae, inflammatory bowel disease and other diseases are associated with varying degrees of chronic pain. Interleukin(IL)-mediated inflammation of the central nervous system(CNS) and sensitization of peripheral nociceptors play an important role in the pathogenesis of chronic pain. This review,guided by interleukin, illustrates the relationship between interleukin and chronic pain, and attempts to provide new strategies for the treatment of chronic pain and new targets for development of new drugs.