精神分裂症患者一级亲属睁眼与闭眼状态下听觉稳态反应特点

Characteristics of auditory steady-state response in first-degree relatives of schizophrenic patients under eye-open/closed state

目的探讨睁眼与闭眼状态对精神分裂症一级亲属40 Hz听觉稳态反应(auditory steady state response,ASSR)的影响。方法选取2010年3月至2011年10月在上海市精神卫生中心就诊的精神分裂症患者的一级亲属38名,同期招募31名健康对照。应用分裂型人格障碍调查问卷(schizotypal personality questionnaire,SPQ)对所有被试进行评估。所有被试均顺序采集睁眼和闭眼状态下各持续3 min的40 Hz脑电ASSR信号。事件相关谱扰动(event-related spectrum perturbation,ERSP)和试次间相位一致性(intertribal phase coherence,ITC)两个指标用于评估ASSR。采用SPSS 22.0软件对数据进行统计分析。双因素方差分析用于睁眼和闭眼两种状态下两组间ITC和ERSP的比较分析。采用Spearman相关分析各指标间的相关性。结果 ITC的组别主效应和组别×睁闭眼交互效应均不显著(均P>0.05),睁闭眼主效应显著(F(1,67) =10.61,P=0.002);健康对照组内睁眼时ITC明显高于闭眼时(P=0.014),一级亲属组内睁眼时ITC高于闭眼时(P=0.039)。ERSP的睁闭眼主效应(F(1,67)=0.195,P=0.660)、组别主效应(F(1,67)=0.627,P=0.431)、组别×睁闭眼交互效应(F(1,67)=1.034,P=0.313)均不显著。Spearman相关分析结果显示,健康对照组内ERSP(睁眼:r=-0.260,P=0.210;闭眼:r=-0.318,P=0.122)、ITC(睁眼:r=-0.248,P=0.232;闭眼:r=-0.260,P=0.209)与SPQ评分均无相关性。精神分裂症一级亲属组内ERSP(睁眼:r=-0.387,P=0.226;闭眼:r=-0.363,P=0.238)、ITC(睁眼:r=0.126,P=0.485;闭眼:r=0.096,P=0.595)与SPQ评分也均无相关性。结论睁眼与闭眼状态下精神分裂症一级亲属40 Hz ASSR的调节模式未明显受损,提示40 Hz ASSR的睁眼与闭眼调节模式可能不是预测精神病遗传高危预后的潜在标记。

Objective To study the effect of eye-open/closed state on 40 Hz auditory steady state response(ASSR)in first-degree relatives of schizophrenia.Methods Thirty-eight first-degree relatives of schizophrenic patients treated in Shanghai Mental Health Center from March 2010 to October 2011 were selected,and 31 healthy controls were recruited in the same period.All subjects were assessed with schizotypal personality questionnaire(SPQ).The 40 Hz EEG ASSR signals lasting for 3 min under open and closed eyes of all subjects were sequentially collected.Event-related spectrum perturbation(ERSP)and intertribal phase coherence(ITC)were used to evaluate ASSR.SPSS 22.0 software was used for statistical analysis.Two-way analysis of variance was used to compare ITC and ERSP between the two groups under open and closed eyes.Spearman correlation analysis was used to analyze the correlation between each measurement.Results ITC in group main effect and group×the eye open/closed interaction effect were not significant(both P>0.05),but the main effect of eye-open and eye-closed was significant(F(1,67)=10.61,P=0.002).In the healthy control group,the ITC in eye-open state was significantly higher than that in eye-closed state(P=0.014),and in the first-degree relatives group,the ITC in eye-open state was higher than that in eyes closed state(P=0.039).ERSP in the main effect of eye-open and eye-closed(F(1,67)=0.195,P=0.660),group main effect(F(1,67)=0.627,P=0.431),group×the eye-open/closed interaction effect(F(1,67)=1.034,P=0.313)was not significant.Spearman correlation analysis showed that there was no correlation between ERSP(eye open:r=-0.260,P=0.210;eye closed:r=-0.318,P=0.122),ITC(eye open:r=-0.248,P=0.232;eye closed:r=-0.260,P=0.209)and SPQ score in the healthy control group.There was also no correlation between ERSP(eye open:r=-0.387,P=0.226;eye closed:r=-0.363,P=0.238)or ITC(eye open:r=0.126,P=0.485;eye closed:r=0.096,P=0.595)and SPQ score in the first-degree relatives group of schizophrenia.Conclusion The regulation pattern of 40 Hz ASSR in schizophrenic first-degree relatives is not significantly impaired in the eye-open/closed state,suggesting that the open/closed regulation pattern of 40 Hz ASSR may not be a potential marker for predicting the genetic high-risk prognosis of schizophrenia.