光照治疗情绪相关疾病的研究进展

Research progress of light therapy for mood disorders

光照治疗(light therapy,LT)作为一种非侵入性的治疗方法,可用于治疗抑郁症、围产期抑郁症、双相情感障碍等多种情绪相关疾病。然而,目前光照治疗调节情绪的神经机制尚不明确,光照治疗的临床应用与其不良反应也尚存争议。光照调节情绪可能与自感光视网膜神经节细胞(intrinsically photosensitive retinal ganglion cells,ipRGCs)介导的感光通路、时钟基因表达、昼夜节律及睡眠结构改变等有关。现就光照治疗在情绪相关疾病中的临床应用现状及其相关的神经生物学机制进行综述,为光照治疗情绪相关疾病的应用及推广提供理论支持。

Light therapy,a non-intrusive approach,is now considered as a promising new treatment method for a variety of mood disorders such as depression,bipolar disorder,postpartum depression and so on.However,the neural mechanism of light therapy to regulate emotions is still unclear,and the clinical application of light therapy and its side effects are still controversial.Light therapy regulates mood may be related to the changes of neural circuit mediated by intrinsically photosensitive retinal ganglion cells(ipRGCs),clock gene expression,circadian rhythm and sleep structure.In this paper,the treatment of mood disorders by light has been discussed,and a variety of neural circuits and molecular biological mechanisms of light therapy are introduced,meanwhile,the current situation and side effects of light therapy have been analyzed,in order to provide evidence for the application and promotion of light therapy in the treatment of mood disorders.