阑尾切除对自身免疫性疾病的影响

Influence of appendectomy on autoimmune diseases

阑尾富含淋巴组织,一直以来被认为有其独特的免疫功能。近年来越来越多的研究表明,在阑尾切除后,人体一些自身免疫性疾病的发病风险有明显的改变,这可能与阑尾切除术后人体免疫功能的变化和肠道微生物组成发生改变有关。本研究从肠道免疫和肠道菌群的角度对阑尾及阑尾切除后相关疾病的发生和发展进行总结,发现阑尾切除主要是通过影响分泌型免疫型球蛋白A(sIgA)的产生、调节性T淋巴细胞的数量及微生物的组成,进而影响了自身免疫性疾病的发病风险。

The appendix is rich in lymphoid tissue and has been seen as an unique immunological organ.In recent years,more and more studies have shown that the onset risk of some autoimmune diseases after appendectomy has obvious change,which could be related with the human body immunological function changes and alterations of intestinal microbiologic composition after appendectomy.This article summaries the occurrence and development of related diseases after appendectomy from the angles of intestinal immunity and intestinal flora,and find that appendectomy may influence the onset risk of autoimmune diseases through affecting the generation of secretory immunoglobulin A(sIgA),number of regulatary T cells and microbial composition.