不同心理状态企业员工血尿酸水平的比较

Comparison of blood uric acid levels among employees with different mental states

目的比较不同心理状态企事业员工血尿酸水平。方法2019年1月至2021年8月在解放军总医院体检的企事业单位员工中选择200例在职员工作为本次研究对象,依据心理压力、焦虑与抑郁程度量表分值,3种心理状态由轻到重各分为4组,经单因素方差分析与Speraman相关性分析,研究对象基线资料、血尿酸水平、肌酐水平和尿素氮水平,探讨不同心理状态与血尿酸水平变化的关系。结果依照心理压力、焦虑、抑郁程度分组比较,心理压力较小、正常、偏高、较大,血尿酸水平分别为(198.52±30.24)μmol/L、(256.52±10.33)μmol/L、(354.20±15.54)μmol/L、(399.20±20.20)μmol/L,4组间有显著差异(F=694.662,P<0.001);无焦虑、轻度焦虑、中度焦虑、重度焦虑,血尿酸水平分别为(210.42±30.20)μmol/L、(256.50±12.33)μmol/L、(355.21±15.16)μmol/L、395.10±16.20μmol/L 4组间有显著差异(F=338.096,P<0.001);无抑郁、轻度抑郁、中度抑郁、重度抑郁,血尿酸水平分别为(200.42±30.45)μmol/L、(258.50±12.35)μmol/L、(356.21±15.14)μmol/L、(395.20±16.21)μmol/L,4组间有显著差异(F=411.244,P<0.001)。不同心理状态的员工血尿酸水平均有统计学差异,且随心理状态变化程度加重致血尿酸水平呈现由低向高逐渐升高的趋势。企事业员工不同心理状态分值与尿酸水平呈正相关关系(r=0.885、0.780、0.794,P<0.05),且血尿酸水平变化与肌酐、尿素氮水平无相关性(r=1.869、3.887、5.798,P>0.05)。结论不同心理状态的企事业员工血尿酸水平不同,且心理压力越大,抑郁、焦虑程度越重,生理指标血尿酸水平亦越高,且血尿酸水平升高与肌酐、尿素氮无关。

Objective To compare the serum uric acid levels among employees with different psychological states.Methods From January 2019 to August 2021,200 in-service employees of various enterprises and public institutions receiving health screening in PLA General Hospital were selected as the participants for this study.Based on the scores of psychological stress,anxiety,and depression scale,each of the three psychological states was divided into four groups from mild to severe.The baseline data,serum uric acid level,creatinine level,and urea nitrogen level of participants were studied to explore the relationship between different psychological states and changes serum uric acid level.Results According to the degree of psychological stress,anxiety,and depression,serum uric acid levels were 198.52±30.24μmol/L,256.52±10.33μmol/L,354.20±15.54μmol/L,and 399.20±20.20μmol/L(F value 694.662,P<0.001),respectively.There was statistical difference in serum uric acid level of employees with different psychological statuses;with the aggravation of psychological status,the serum uric acid level showed a trend of gradually increasing from low to high.There was a positive correlation between the scores of different psychological states and uric acid level(r=0.885,0.780,0.794,P<0.05),and no correlation between uric acid level and creatinine and urea nitrogen levels(r=1.869,3.887,5.798,P>0.05).Conclusions The serum uric acid level of employees varied with different types of psychological states.The greater the psychological stress is,the more serious the degree of depression and anxiety and the higher the serum uric acid level would be.The increase in uric acid level has no relationship with creatinine and urea nitrogen level.