中药有效成分对AD相关认知功能的改善作用及其机制研究进展

Research progress on the effective components of traditional Chinese medicine for improving AD-related cognitive impairment

随着社会老龄化的到来,阿尔茨海默病(Alzheimer’s disease,AD)等衰老相关疾病已经成为我国面临的重要公共卫生和社会问题,但目前所有的临床药物均未能成功逆转AD的病理进程。经过多年的研究,我国传统中药在认知功能改善方面积累了大量的临床实践经验,相较于针对单分子靶点的西药,中药可通过多条分子通路改善AD的认知障碍,在防治AD药物的研发中体现出了巨大潜力。本综述基于AD发病的中西医机制认识,总结了经典中药方及其有效成分在改善AD相关认知功能障碍方面的效应,并阐述了典方及疗效化合物改善认知的作用靶点和相关分子机制。深入探索中药及有效成分发挥作用的多条分子通路,采用多靶点的干预对于AD防治具有重要意义。

Alzheimer’s disease(AD)and other aging-related diseases have become an important public health issue in China.However,current clinical drugs have failed to reverse the pathological process of AD.The holistic approach of traditional Chinese medicine offers advantages in improving cognitive function in AD through multiple molecular pathways,and may have potential for preventing AD.This paper summarizes the effects of classical traditional Chinese medicine and its active components in the improvement of AD-related cognitive dysfunction and describes the functional targets and related molecular mechanisms.This may have significance for the prevention and treatment of AD through multi-target intervention.