噬菌体展示技术及其在抗病毒药物发现中的应用

Phage display technology and its application in antivirals discovery

新冠肺炎的大暴发再次引起了人们对于病毒感染性疾病的关注,研发抗病毒药物对于已知的和可能新出现的病毒都具有重要意义。近年来,多肽和蛋白质类药物正成为抗病毒药物研发领域的热点,噬菌体展示技术作为筛选发现多肽和蛋白类药物的有力工具也日益被学术界和工业界所关注。本文介绍了噬菌体展示技术的基本原理,对常用于抗病毒药物发现的噬菌体展示文库进行了总结,对目前噬菌体文库来源的抗病毒药物的不足及其相关改进策略进行了讨论,并对噬菌体展示技术在抗病毒药物开发中的应用前景进行了展望。

The COVID-19 outbreak has drawn attention to viral infectious diseases once again, and the development of antiviral drugs for both known and potentially emerging viruses is of great significance. In recent years, peptides and protein drugs are becoming a hot spot in the field of antiviral drug research and development.Phage display technology, as a powerful tool for screening peptides and protein drugs, has been increasingly concerned in the academic and industrial fields. The present review introduced the basic principle of phage display technology, summarized phage display libraries often used in antiviral drug discovery and their applications,discussed the challenges and future direction of antiviral drug research and development based on phage display technology.