摘要
细胞衰老的显著特征是永久的细胞周期停滞,同时伴随细胞代谢、表观遗传调控等变化。阿尔茨海默症(AD)是一种常见的神经退行性疾病,主要症状为记忆力减退和认知功能障碍。大量研究表明,星形胶质细胞和小胶质细胞等中枢神经系统细胞的衰老与AD的发生密切相关,抑制脑细胞衰老有望为AD的防治提供新思路和治疗策略。本文综述了脑细胞衰老在AD发病中的潜在作用及机制、脑细胞之间的相互影响,从而为AD病理机制研究及抗AD药物研发提供新的方向。
Cell senescence is characterized by permanent cell cycle arrest, accompanied by the changes in cell metabolism and epigenetic regulation. Alzheimer’s disease(AD) is a common neurodegenerative disease, with the main symptoms of memory loss and cognitive impairment. A large number of studies have shown that the senescence of central nervous system cells such as astrocytes and microglia is closely related to the occurrence of AD. Inhibition of brain cell senescence is expected to provide new ideas and therapeutic strategies for the prevention and treatment of AD. This paper reviews the potential roles and mechanisms of senescence of brain cells in AD, and interaction effects among brain cells. This review will provide a new direction for the study of pathological mechanism of AD and the development of anti-AD drugs.
作者
刘雨欣
秦雪梅
高丽
LIU Yu-xin;QIN Xue-mei;GAO Li(Modern Research Center for Traditional Chinese Medicine,Shanxi University,Taiyuan 030006,China;The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education,Shanxi University,Taiyuan 030006,China;The Key Laboratory of Effective Substances Research andUtilization in TCM of Shanxi Province,Taiyuan 030006,China)
出处
《药学学报》
CAS
CSCD
北大核心
2022年第7期1946-1953,共8页
Acta Pharmaceutica Sinica
基金
国家自然科学基金青年基金资助项目(81603319)
山西省面上青年基金资助项目(201801D221374)。
