益生元在药物递送系统中的研究进展

Research progress of prebiotics in drug delivery system

随着对肠道微生物研究的深入,肠道菌群对人类健康的影响受到关注,已成为当前生命科学和医学的研究热点,也被认为是疾病治疗的重要靶点。益生元可调节肠道菌群的组成和功能从而改善宿主健康。碳水化合物是最基本的益生元,其独特的理化性质及肠道菌调节能力可在实现药物靶向递送的同时又能促进肠道健康,从而对疾病的治疗发挥积极作用。本文对不同种类的益生元及其肠道菌调节机制进行了阐述,介绍了碳水化合物类益生元在药物递送系统中的研究进展,并对其应用前景进行展望,以期为相关研究提供参考。

With the in-depth study on the gut microflora,the impact of intestinal bacteria on human health has attracted more and more attention.It has become a research hotspot in life science and medicine,and is considered as an important target of disease control.Prebiotics can regulate the composition and function of intestinal flora and then improve host health.Carbohydrate is the most basic prebiotic.Its unique physiochemical characteristics and gut microbiota-regulating ability make it a promising ingredient for achieving drug target delivery and intestinal health promotion.In this paper,different kinds of prebiotics and their regulation mechanism of intestinal bacteria were illuminated.Moreover,the research progress of carbohydrate prebiotics in drug delivery system was elucidated,and its application prospect is prospected,so as to provide reference for related research.