细胞焦亡与肺癌研究进展

Advances in Research on Pyroptosis and Lung Cancer

细胞焦亡是由炎症小体引发的细胞炎症性坏死形式,其特点是半胱氨酸蛋白酶介导促炎因子和Gasdermin家族蛋白活化,导致膜孔形成、细胞肿胀、质膜裂解、染色质碎裂和细胞内促炎内容物释放。炎症小体存在于多种肿瘤细胞,可以通过介导细胞焦亡影响肿瘤的增殖、侵袭和转移。研究发现细胞焦亡与肺癌发病、进展、预后及耐药的发生密切相关,归纳总结细胞焦亡的分子机制及其在肺癌治疗中的研究进展,有利于为肺癌的诊疗和新药研发提供新的依据。

Pyroptosis is a form of inflammatory necrosis caused by inflammatory bodies. It is characterized by caspase mediated activation of inflammatory cytokines and Gasdermin family proteins, resulting in membrane pore formation, cell swelling, plasma membrane lysis, chromatin fragmentation and release of intracellular pro-inflammatory contents. Inflammatory corpuscles exist in a variety of tumor cells. Inflammatory corpuscles can affect tumor proliferation, invasion and metastasis by mediating cell death. It is found that cell death is closely related to the pathogenesis, progress, prognosis and drug resistance of lung cancer. Summarizing the molecular mechanism of cell death and its research progress in the treatment of lung cancer is helpful to provide a new basis for the diagnosis and treatment of lung cancer and the development of new drugs.