5种肿瘤血清标志物联合检测与任一单项检测评估肺癌的灵敏度比较

Comparison of sensitivities of combined detection of five serum tumor markers and any single detection in evaluating lung cancer

目的:探讨5种肿瘤血清标志物联合检测与任一单项检测评估肺癌的灵敏度。方法:择取2018年8月~2020年8月因肺癌前来本院就诊的108例肺鳞癌为观察组A,因病理数有限,按照成组匹配病例对照研究模式,选择50例肺腺癌为观察组B,32例小细胞肺癌为观察组C,合计190例为观察组,同期择取肺部良性疾病患者190例为对照组,行癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)、糖类抗原(CA125)、神经元特异性烯醇化酶(NSE)及鳞状细胞癌抗原(SCCAg)五类肿瘤血清标志物单一及联合检测,比较各组肿瘤血清标志物水平,分析单一及联合检测灵敏度。结果:观察组中A、B及C组CEA、CYFRA21-1、CA125、SCCAg及NSE水平均较对照组更高(P<0.05);5种肿瘤血清标志物联合检测,对照组、观察组A、观察组B及观察组C灵敏度均显著高于单一肿瘤血清标志物检测(P<0.05)。结论:肺癌患者肿瘤血清标志物均较肺部良性疾病患者水平更高,其检测有助于临床诊断,且5种肿瘤血清标志物联合检测灵敏度较单一检测更高,诊断效果得到明显提升。

Objective:To explore the sensitivities of combined detection of five serum tumor markers and any single detection in evaluating lung cancer.Methods:108 cases of lung squamous cell carcinoma who came to this hospital due to lung cancer between August 2018 and August 2020 were selected as the observation group A.Due to the limited number of pathologies,50 cases oflung adenocarcinoma were selected as the observation group B and 32 cases of small cell lung cancer were set as the observation group C according to the group-matched case-control study model,thus a total of 190 cases were in observation group.190 patients with benign lung diseases were selected as the control group during the same period.The single detection and combined detection of five types of serum tumor markers of carcinoembryonic antigen(CEA),cytokeratin 19 fragment(CYFRA21-1),carbohydrate antigen(CA125),neuron specific enolase(NSE)and squamous cell carcinoma antigen(SCCAg)were performed,and the levels of serum tumor markers were compared among the groups,and the sensitivities of single detection and combined detection were analyzed.Results:The levels of CEA,CYFRA21-1,CAI 25,SCCAg and NSE in the observation groups A,B and C were higher than those in the control group(P<0.05).The sensitivities of combined detection of five serum tumor markers in the control group,the observation group A,the observation group B and the observation group C were significantly higher than those of single serum tumor marker detection(P<0.05).Con elusion:The levels of serum tumor markers in patients with lung cancer are higher than those in patients with benign lung diseases,and their detection is helpful for clinical diagnosis.The combined detection of five serum tumor markers has higher sensitivity than single detection,and its diagnostic effect is significantly improved.