脐血降钙素原对早期诊断新生儿宫内细菌感染的临床分析

Clinical analysis of procalcitonin in cord blood for early diagnosis of intrauterine bacterial infection in neonates

目的:探讨脐带血降鈣素原(PCT)检查在新生儿宫内细菌感染(IBI)早期诊断中的临床效果。方法:选取2018年3月~2019年4月在本院分娩的260例新生儿作为研究对象,其中足月非感染组200例,早产感染组34例,足月感染组26例,3组均抽取脐带血分别采用酶联免疫法和免疫比浊法行PCT和CRP检测,并对比检测结果。结果:早产感染组、足月感染组脐带血PCT、CRP水平相比足月非感染组均显著更高(P<0.05),但感染组间对比,差异无统计学意义(P>0.05);PCT+CRP检测诊断IBI的阳性率相比PCT检测、CRP检测均显著升高(P<0.05);PCT、CRP检测诊断阳性率比较差异无统计学意义(P>0.05)。结论:脐带血PCT检测用于IBI早期诊断表现出较高应用价值,对早期诊治有一定意义,但与CRP检測联合应用有望获得更理想诊断效能。

Objective:To investigate the clinical effect of PCT in the early diagnosis of neonatal intrauterine bacterial infection(IBI).Methods:260 newborns deEvered in our hospital from March 2018 to April 2019 were selected as the research objects.200 full-tenn non infected children were taken as the full-term non infected group,34 preterm intrauterine infected children as the preterm infected group,26 full-term intrauterine infected children as the fiill-tenn infected group.Cord blood was taken from three groups for PCT detection,and the results were analyzed and compared.Results:PCT and CRP levels of cord blood in preterm delivery infection group and term infection group were significantly higher than those in non infection group(P<0.05),but there was no significant di&rence between the infection groups(P>0.05);The positive rate of PCT+CRP in the diagnosis of IBI was significantly higher than PCT and CRP(P<0.05);There was no significant di&rence in the positive rate of PCT and CRP(P>0.05).Conclusion:PCT detection of cord blood in the early diagnosis ofIBI has a high value,which has a certain significance for the early diagnosis and treatment,but the combination of PCT detection and CRP detection is expected to achieve a better diagnosis efficiency.