白藜芦醇治疗肾脏疾病的分子机制研究进展

Advances in the molecular mechanism of resveratrol in the treatment of kidney diseases

肾脏疾病是一类影响人体健康的常见病。白藜芦醇(Res)是从植物中提取的天然多酚类化合物,具有抗炎、抗肿瘤、抗氧化、抗衰老、抗细胞凋亡等多种药理学活性,具有治疗诸多疾病的潜力和靶点。目前已发现Res在糖尿病肾病、肾结石、急性肾损伤等肾脏疾病中均起到缓解作用,其机制为抑制氧化应激反应、细胞凋亡,调节Shh、Nrf2/ARE、NF-κB、mTOR、PI3K/Akt信号通路,激活细胞焦亡等,从而对肾脏起到保护作用。

Kidney diseases are a group of common diseases that affect human health.Resveratrol(Res)is a natural polyphenolic compound extracted from plants with various pharmacological activities such as anti-inflammatory,anti-tumor,antioxidant,anti-aging and anti-apoptotic ones,which has the potential and target for the treatment of many diseases.Res has been found to play an alleviating role in renal diseases such as diabetic nephropathy,renal calculi,and acute kidney injury.The mechanisms are inhibition of oxidative stress response and apoptosis,regulation of Shh,Nrf2/ARE,NF-κB,mTOR,PI3K/Akt signaling pathways,and activation of cellular scorching,thus providing a protective effect on the kidney.